A low-threshold potassium current enhances sparseness and reliability in a model of avian auditory cortex

Birdsong is a complex vocal communication signal, and like humans, birds need to discriminate between similar sequences of sound with different meanings. The caudal mesopallium (CM) is a cortical-level auditory area implicated in song discrimination. CM neurons respond sparsely to conspecific song and are tolerant of production variability. Intracellular recordings in CM have identified a diversity of intrinsic membrane dynamics, which could contribute to the emergence of these higher-order functional properties. We investigated this hypothesis using a novel linear-dynamical cascade model that incorporated detailed biophysical dynamics to simulate auditory responses to birdsong. Neuron models that included a low-threshold potassium current present in a subset of CM neurons showed increased selectivity and coding efficiency relative to models without this current. These results demonstrate the impact of intrinsic dynamics on sensory coding and the importance of including the biophysical characteristics of neural populations in simulation studies.Author summary: Maintaining a stable mental representation of an object is an important task for sensory systems, requiring both recognizing the features required for identification and ignoring incidental changes in its presentation. The prevailing explanation for these processes emphasizes precise sets of connections between neurons that capture only the essential features of an object. However, the intrinsic dynamics of the neurons themselves, which determine how these inputs are transformed into spiking outputs, may also contribute to the neural computations underlying object recognition. To understand how intrinsic dynamics contribute to sensory coding, we constructed a computational model capable of simulating a neural response to an auditory stimulus using a detailed description of different intrinsic dynamics in a higher-order avian auditory area. The results of our simulation showed that intrinsic dynamics can have a profound effect on processes underlying object recognition. These findings challenge the view that patterns of connectivity alone account for the emergence of stable object representations and encourage greater consideration of the functional implications of the diversity of neurons in the brain.