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Myelination and excitation-inhibition balance synergistically shape structure-function coupling across the human cortex

Author

Listed:
  • Panagiotis Fotiadis

    (University of Pennsylvania
    University of Pennsylvania)

  • Matthew Cieslak

    (University of Pennsylvania)

  • Xiaosong He

    (University of Science and Technology of China)

  • Lorenzo Caciagli

    (University of Pennsylvania)

  • Mathieu Ouellet

    (University of Pennsylvania)

  • Theodore D. Satterthwaite

    (University of Pennsylvania)

  • Russell T. Shinohara

    (University of Pennsylvania
    University of Pennsylvania)

  • Dani S. Bassett

    (University of Pennsylvania
    University of Pennsylvania
    University of Pennsylvania
    University of Pennsylvania)

Abstract

Recent work has demonstrated that the relationship between structural and functional connectivity varies regionally across the human brain, with reduced coupling emerging along the sensory-association cortical hierarchy. The biological underpinnings driving this expression, however, remain largely unknown. Here, we postulate that intracortical myelination and excitation-inhibition (EI) balance mediate the heterogeneous expression of structure-function coupling (SFC) and its temporal variance across the cortical hierarchy. We employ atlas- and voxel-based connectivity approaches to analyze neuroimaging data acquired from two groups of healthy participants. Our findings are consistent across six complementary processing pipelines: 1) SFC and its temporal variance respectively decrease and increase across the unimodal-transmodal and granular-agranular gradients; 2) increased myelination and lower EI-ratio are associated with more rigid SFC and restricted moment-to-moment SFC fluctuations; 3) a gradual shift from EI-ratio to myelination as the principal predictor of SFC occurs when traversing from granular to agranular cortical regions. Collectively, our work delivers a framework to conceptualize structure-function relationships in the human brain, paving the way for an improved understanding of how demyelination and/or EI-imbalances induce reorganization in brain disorders.

Suggested Citation

  • Panagiotis Fotiadis & Matthew Cieslak & Xiaosong He & Lorenzo Caciagli & Mathieu Ouellet & Theodore D. Satterthwaite & Russell T. Shinohara & Dani S. Bassett, 2023. "Myelination and excitation-inhibition balance synergistically shape structure-function coupling across the human cortex," Nature Communications, Nature, vol. 14(1), pages 1-21, December.
  • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-41686-9
    DOI: 10.1038/s41467-023-41686-9
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