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Orthogonalization of spontaneous and stimulus-driven activity by hierarchical neocortical areal network in primates

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  • Teppei Matsui

    (The University of Tokyo
    Doshisha University
    Kyushu University
    Japan Science and Technology Agency)

  • Takayuki Hashimoto

    (The University of Tokyo
    Kyushu University
    The University of Tokyo)

  • Tomonari Murakami

    (The University of Tokyo
    Kyushu University
    The University of Tokyo)

  • Masato Uemura

    (The University of Tokyo
    Kyushu University
    The University of Tokyo
    Kansai Medical University)

  • Kohei Kikuta

    (The University of Tokyo
    The University of Tokyo)

  • Toshiki Kato

    (The University of Tokyo
    The University of Tokyo)

  • Kenichi Ohki

    (The University of Tokyo
    Kyushu University
    The University of Tokyo
    The University of Tokyo)

Abstract

How biological neural networks reliably process information in the presence of spontaneous activity remains controversial. In mouse primary visual cortex (V1), stimulus-evoked and spontaneous activity show orthogonal (dissimilar) patterns, which is advantageous for separating sensory signals from internal noise. However, studies in carnivore and primate V1, which have functional columns, have reported high similarity between stimulus-evoked and spontaneous activity. Thus, the mechanism of signal-noise separation in the columnar visual cortex may be different from that in rodents. To address this issue, we compared spontaneous and stimulus-evoked activity in marmoset V1 and higher visual areas. In marmoset V1, spontaneous and stimulus-evoked activity showed similar patterns as expected. However, in marmoset higher visual areas, spontaneous and stimulus-evoked activity were progressively orthogonalized along the cortical hierarchy, eventually reaching levels comparable to those in mouse V1. These results suggest that orthogonalization of spontaneous and stimulus-evoked activity is a general principle of cortical computation.

Suggested Citation

  • Teppei Matsui & Takayuki Hashimoto & Tomonari Murakami & Masato Uemura & Kohei Kikuta & Toshiki Kato & Kenichi Ohki, 2024. "Orthogonalization of spontaneous and stimulus-driven activity by hierarchical neocortical areal network in primates," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-54322-x
    DOI: 10.1038/s41467-024-54322-x
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    References listed on IDEAS

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