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Hippocampal connectivity patterns echo macroscale cortical evolution in the primate brain

Author

Listed:
  • Nicole Eichert

    (University of Oxford)

  • Jordan DeKraker

    (McGill University)

  • Amy F. D. Howard

    (University of Oxford)

  • Istvan N. Huszar

    (University of Oxford)

  • Silei Zhu

    (University of Oxford)

  • Jérôme Sallet

    (University of Oxford
    Univ Lyon)

  • Karla L. Miller

    (University of Oxford)

  • Rogier B. Mars

    (University of Oxford
    Radboud University Nijmegen)

  • Saad Jbabdi

    (University of Oxford)

  • Boris C. Bernhardt

    (McGill University)

Abstract

While the hippocampus is key for human cognitive abilities, it is also a phylogenetically old cortex and paradoxically considered evolutionarily preserved. Here, we introduce a comparative framework to quantify preservation and reconfiguration of hippocampal organisation in primate evolution, by analysing the hippocampus as an unfolded cortical surface that is geometrically matched across species. Our findings revealed an overall conservation of hippocampal macro- and micro-structure, which shows anterior-posterior and, perpendicularly, subfield-related organisational axes in both humans and macaques. However, while functional organisation in both species followed an anterior-posterior axis, we observed a marked reconfiguration in the latter across species, which mirrors a rudimentary integration of the default-mode-network in non-human primates. Here we show that microstructurally preserved regions like the hippocampus may still undergo functional reconfiguration in primate evolution, due to their embedding within heteromodal association networks.

Suggested Citation

  • Nicole Eichert & Jordan DeKraker & Amy F. D. Howard & Istvan N. Huszar & Silei Zhu & Jérôme Sallet & Karla L. Miller & Rogier B. Mars & Saad Jbabdi & Boris C. Bernhardt, 2024. "Hippocampal connectivity patterns echo macroscale cortical evolution in the primate brain," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
  • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-49823-8
    DOI: 10.1038/s41467-024-49823-8
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