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Feedback driven autonomous cycles of assembly and disassembly from minimal building blocks

Author

Listed:
  • Antara Reja

    (Indian Institute of Science Education and Research (IISER) Kolkata)

  • Sangam Jha

    (Indian Institute of Science Education and Research (IISER) Kolkata)

  • Ashley Sreejan

    (CSIR-National Chemical Laboratory
    Academy of Scientific and Innovative Research (AcSIR))

  • Sumit Pal

    (Indian Institute of Science Education and Research (IISER) Kolkata)

  • Subhajit Bal

    (Indian Institute of Science Education and Research (IISER) Kolkata)

  • Chetan Gadgil

    (CSIR-National Chemical Laboratory
    Academy of Scientific and Innovative Research (AcSIR)
    CSIR-Institute of Genomics and Integrative Biology)

  • Dibyendu Das

    (Indian Institute of Science Education and Research (IISER) Kolkata)

Abstract

The construction of complex systems by simple chemicals that can display emergent network dynamics might contribute to our understanding of complex behavior from simple organic reactions. Here we design single amino acid/dipeptide-based systems that exhibit multiple periodic changes of (dis)assembly under non-equilibrium conditions in closed system, importantly in the absence of evolved biocatalysts. The two-component based building block exploits pH driven non-covalent assembly and time-delayed accelerated catalysis from self-assembled state to install orthogonal feedback loops with a single batch of reactants. Mathematical modelling of the reaction network establishes that the oscillations are transient for this network structure and helps to predict the relative contribution of the feedback loop to the ability of the system to exhibit such transient oscillation. Such autonomous systems with purely synthetic molecules are the starting point that can enable the design of active materials with emergent properties.

Suggested Citation

  • Antara Reja & Sangam Jha & Ashley Sreejan & Sumit Pal & Subhajit Bal & Chetan Gadgil & Dibyendu Das, 2024. "Feedback driven autonomous cycles of assembly and disassembly from minimal building blocks," Nature Communications, Nature, vol. 15(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-54197-y
    DOI: 10.1038/s41467-024-54197-y
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    References listed on IDEAS

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