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Feedback control of intercellular signalling in development

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  • Matthew Freeman

    (MRC Laboratory of Molecular Biology)

Abstract

The intercellular communication that regulates cell fate during animal development must be precisely controlled to avoid dangerous errors. How is this achieved? Recent work has highlighted the importance of positive and negative feedback loops in the dynamic regulation of developmental signalling. These feedback interactions can impart precision, robustness and versatility to intercellular signals. Feedback failure can cause disease.

Suggested Citation

  • Matthew Freeman, 2000. "Feedback control of intercellular signalling in development," Nature, Nature, vol. 408(6810), pages 313-319, November.
    • Handle: RePEc:nat:nature:v:408:y:2000:i:6810:d:10.1038_35042500
    DOI: 10.1038/35042500
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    Citations

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    Cited by:

    1. Ariel L Rivas & Mark D Jankowski & Renata Piccinini & Gabriel Leitner & Daniel Schwarz & Kevin L Anderson & Jeanne M Fair & Almira L Hoogesteijn & Wilfried Wolter & Marcelo Chaffer & Shlomo Blum & Tom, 2013. "Feedback-Based, System-Level Properties of Vertebrate-Microbial Interactions," PLOS ONE, Public Library of Science, vol. 8(2), pages 1-16, February.
    2. Hui Zhang & Yueling Chen & Yong Chen, 2012. "Noise Propagation in Gene Regulation Networks Involving Interlinked Positive and Negative Feedback Loops," PLOS ONE, Public Library of Science, vol. 7(12), pages 1-8, December.
    3. Stefano Ciliberti & Olivier C Martin & Andreas Wagner, 2007. "Robustness Can Evolve Gradually in Complex Regulatory Gene Networks with Varying Topology," PLOS Computational Biology, Public Library of Science, vol. 3(2), pages 1-10, February.
    4. Jens Grauer & Falko Schmidt & Jesús Pineda & Benjamin Midtvedt & Hartmut Löwen & Giovanni Volpe & Benno Liebchen, 2021. "Active droploids," Nature Communications, Nature, vol. 12(1), pages 1-8, December.
    5. Zhou, Peipei & Cai, Shuiming & Liu, Zengrong & Chen, Luonan & Wang, Ruiqi, 2013. "Coupling switches and oscillators as a means to shape cellular signals in biomolecular systems," Chaos, Solitons & Fractals, Elsevier, vol. 50(C), pages 115-126.
    6. Sriram, K., 2006. "Effects of positive electrical feedback in the oscillating Belousov–Zhabotinsky reaction: Experiments and simulations," Chaos, Solitons & Fractals, Elsevier, vol. 28(4), pages 1055-1066.
    7. Merav Socolovsky & Michael Murrell & Ying Liu & Ramona Pop & Ermelinda Porpiglia & Andre Levchenko, 2007. "Negative Autoregulation by FAS Mediates Robust Fetal Erythropoiesis," PLOS Biology, Public Library of Science, vol. 5(10), pages 1-16, September.
    8. Rutger Hermsen & Bas Ursem & Pieter Rein ten Wolde, 2010. "Combinatorial Gene Regulation Using Auto-Regulation," PLOS Computational Biology, Public Library of Science, vol. 6(6), pages 1-13, June.

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