IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v408y2000i6810d10.1038_35042500.html
   My bibliography  Save this article

Feedback control of intercellular signalling in development

Author

Listed:
  • Matthew Freeman

    (MRC Laboratory of Molecular Biology)

Abstract

The intercellular communication that regulates cell fate during animal development must be precisely controlled to avoid dangerous errors. How is this achieved? Recent work has highlighted the importance of positive and negative feedback loops in the dynamic regulation of developmental signalling. These feedback interactions can impart precision, robustness and versatility to intercellular signals. Feedback failure can cause disease.

Suggested Citation

  • Matthew Freeman, 2000. "Feedback control of intercellular signalling in development," Nature, Nature, vol. 408(6810), pages 313-319, November.
  • Handle: RePEc:nat:nature:v:408:y:2000:i:6810:d:10.1038_35042500
    DOI: 10.1038/35042500
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/35042500
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.

    File URL: https://libkey.io/10.1038/35042500?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Ariel L Rivas & Mark D Jankowski & Renata Piccinini & Gabriel Leitner & Daniel Schwarz & Kevin L Anderson & Jeanne M Fair & Almira L Hoogesteijn & Wilfried Wolter & Marcelo Chaffer & Shlomo Blum & Tom, 2013. "Feedback-Based, System-Level Properties of Vertebrate-Microbial Interactions," PLOS ONE, Public Library of Science, vol. 8(2), pages 1-16, February.
    2. Hui Zhang & Yueling Chen & Yong Chen, 2012. "Noise Propagation in Gene Regulation Networks Involving Interlinked Positive and Negative Feedback Loops," PLOS ONE, Public Library of Science, vol. 7(12), pages 1-8, December.
    3. Stefano Ciliberti & Olivier C Martin & Andreas Wagner, 2007. "Robustness Can Evolve Gradually in Complex Regulatory Gene Networks with Varying Topology," PLOS Computational Biology, Public Library of Science, vol. 3(2), pages 1-10, February.
    4. Jens Grauer & Falko Schmidt & Jesús Pineda & Benjamin Midtvedt & Hartmut Löwen & Giovanni Volpe & Benno Liebchen, 2021. "Active droploids," Nature Communications, Nature, vol. 12(1), pages 1-8, December.
    5. Zhou, Peipei & Cai, Shuiming & Liu, Zengrong & Chen, Luonan & Wang, Ruiqi, 2013. "Coupling switches and oscillators as a means to shape cellular signals in biomolecular systems," Chaos, Solitons & Fractals, Elsevier, vol. 50(C), pages 115-126.
    6. Sriram, K., 2006. "Effects of positive electrical feedback in the oscillating Belousov–Zhabotinsky reaction: Experiments and simulations," Chaos, Solitons & Fractals, Elsevier, vol. 28(4), pages 1055-1066.
    7. Merav Socolovsky & Michael Murrell & Ying Liu & Ramona Pop & Ermelinda Porpiglia & Andre Levchenko, 2007. "Negative Autoregulation by FAS Mediates Robust Fetal Erythropoiesis," PLOS Biology, Public Library of Science, vol. 5(10), pages 1-16, September.
    8. Rutger Hermsen & Bas Ursem & Pieter Rein ten Wolde, 2010. "Combinatorial Gene Regulation Using Auto-Regulation," PLOS Computational Biology, Public Library of Science, vol. 6(6), pages 1-13, June.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:408:y:2000:i:6810:d:10.1038_35042500. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.