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Selenium catalysis enables negative feedback organic oscillators

Author

Listed:
  • Xiuxiu Li

    (Weizmann Institute of Science
    Southern University of Science and Technology)

  • Polina Fomitskaya

    (Weizmann Institute of Science)

  • Viktoryia A. Smaliak

    (Weizmann Institute of Science)

  • Barbara S. Smith

    (Arizona State University)

  • Ekaterina V. Skorb

    (ITMO University)

  • Sergey N. Semenov

    (Weizmann Institute of Science)

Abstract

The construction of materials regulated by chemical reaction networks requires regulatory motifs that can be stacked together into systems with desired properties. Multiple autocatalytic reactions producing thiols are known. However, negative feedback loop motifs are unavailable for thiol chemistry. Here, we develop a negative feedback loop based on the selenocarbonates. In this system, thiols induce the release of aromatic selenols that catalyze the oxidation of thiols by organic peroxides. This negative feedback loop has two important features. First, catalytic oxidation of thiols follows Michaelis-Menten-like kinetics, thus increasing nonlinearity for the negative feedback. Second, the strength of the negative feedback can be tuned by varying substituents in selenocarbonates. When combined with the autocatalytic production of thiols in a flow reactor, this negative feedback loop induces sustained oscillations. The availability of this negative feedback motif enables the future construction of oscillatory, homeostatic, adaptive, and other regulatory circuits in life-inspired systems and materials.

Suggested Citation

  • Xiuxiu Li & Polina Fomitskaya & Viktoryia A. Smaliak & Barbara S. Smith & Ekaterina V. Skorb & Sergey N. Semenov, 2024. "Selenium catalysis enables negative feedback organic oscillators," Nature Communications, Nature, vol. 15(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-47714-6
    DOI: 10.1038/s41467-024-47714-6
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    References listed on IDEAS

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    1. Ximin He & Michael Aizenberg & Olga Kuksenok & Lauren D. Zarzar & Ankita Shastri & Anna C. Balazs & Joanna Aizenberg, 2012. "Synthetic homeostatic materials with chemo-mechano-chemical self-regulation," Nature, Nature, vol. 487(7406), pages 214-218, July.
    2. Alexander I. Novichkov & Anton I. Hanopolskyi & Xiaoming Miao & Linda J. W. Shimon & Yael Diskin-Posner & Sergey N. Semenov, 2021. "Autocatalytic and oscillatory reaction networks that form guanidines and products of their cyclization," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
    3. Matthijs Harmsel & Oliver R. Maguire & Sofiya A. Runikhina & Albert S. Y. Wong & Wilhelm T. S. Huck & Syuzanna R. Harutyunyan, 2023. "A catalytically active oscillator made from small organic molecules," Nature, Nature, vol. 621(7977), pages 87-93, September.
    4. Sergey N. Semenov & Lewis J. Kraft & Alar Ainla & Mengxia Zhao & Mostafa Baghbanzadeh & Victoria E. Campbell & Kyungtae Kang & Jerome M. Fox & George M. Whitesides, 2016. "Autocatalytic, bistable, oscillatory networks of biologically relevant organic reactions," Nature, Nature, vol. 537(7622), pages 656-660, September.
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