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Circuit-based interrogation of sleep control

Author

Listed:
  • Franz Weber

    (Helen Wills Neuroscience Institute, Howard Hughes Medical Institute, University of California)

  • Yang Dan

    (Helen Wills Neuroscience Institute, Howard Hughes Medical Institute, University of California)

Abstract

Sleep is a fundamental biological process observed widely in the animal kingdom, but the neural circuits generating sleep remain poorly understood. Understanding the brain mechanisms controlling sleep requires the identification of key neurons in the control circuits and mapping of their synaptic connections. Technical innovations over the past decade have greatly facilitated dissection of the sleep circuits. This has set the stage for understanding how a variety of environmental and physiological factors influence sleep. The ability to initiate and terminate sleep on command will also help us to elucidate its functions within and beyond the brain.

Suggested Citation

  • Franz Weber & Yang Dan, 2016. "Circuit-based interrogation of sleep control," Nature, Nature, vol. 538(7623), pages 51-59, October.
    • Handle: RePEc:nat:nature:v:538:y:2016:i:7623:d:10.1038_nature19773
    DOI: 10.1038/nature19773
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    Cited by:

    1. Sasa Teng & Fenghua Zhen & Li Wang & Jose Canovas Schalchli & Jane Simko & Xinyue Chen & Hao Jin & Christopher D. Makinson & Yueqing Peng, 2022. "Control of non-REM sleep by ventrolateral medulla glutamatergic neurons projecting to the preoptic area," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    2. Beverly Setzer & Nina E. Fultz & Daniel E. P. Gomez & Stephanie D. Williams & Giorgio Bonmassar & Jonathan R. Polimeni & Laura D. Lewis, 2022. "A temporal sequence of thalamic activity unfolds at transitions in behavioral arousal state," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    3. Qiang Liu & Benjamin J. Bell & Dong Won Kim & Sang Soo Lee & Mehmet F. Keles & Qili Liu & Ian D. Blum & Annette A. Wang & Elijah J. Blank & Jiali Xiong & Joseph L. Bedont & Anna J. Chang & Habon Issa , 2023. "A clock-dependent brake for rhythmic arousal in the dorsomedial hypothalamus," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    4. Layton Lamsam & Brett Gu & Mingli Liang & George Sun & Kamren J. Khan & Kevin N. Sheth & Lawrence J. Hirsch & Christopher Pittenger & Alfred P. Kaye & John H. Krystal & Eyiyemisi C. Damisah, 2024. "The human claustrum tracks slow waves during sleep," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    5. Yalin Yu & Yue Qiu & Gen Li & Kaiwei Zhang & Binshi Bo & Mengchao Pei & Jingjing Ye & Garth J. Thompson & Jing Cang & Fang Fang & Yanqiu Feng & Xiaojie Duan & Chuanjun Tong & Zhifeng Liang, 2023. "Sleep fMRI with simultaneous electrophysiology at 9.4 T in male mice," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    6. Ya-Nan Zhao & Jian-Bo Jiang & Shi-Yuan Tao & Yang Zhang & Ze-Ka Chen & Wei-Min Qu & Zhi-Li Huang & Su-Rong Yang, 2022. "GABAergic neurons in the rostromedial tegmental nucleus are essential for rapid eye movement sleep suppression," Nature Communications, Nature, vol. 13(1), pages 1-18, December.

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