Author
Listed:
- Hiroaki Norimoto
(Max Planck Institute for Brain Research)
- Lorenz A. Fenk
(Max Planck Institute for Brain Research)
- Hsing-Hsi Li
(Max Planck Institute for Brain Research)
- Maria Antonietta Tosches
(Max Planck Institute for Brain Research
Columbia University)
- Tatiana Gallego-Flores
(Max Planck Institute for Brain Research)
- David Hain
(Max Planck Institute for Brain Research
Goethe University)
- Sam Reiter
(Max Planck Institute for Brain Research
Okinawa Institute of Science and Technology Graduate University)
- Riho Kobayashi
(Max Planck Institute for Brain Research
Nagoya City University)
- Angeles Macias
(Max Planck Institute for Brain Research)
- Anja Arends
(Max Planck Institute for Brain Research)
- Michaela Klinkmann
(Max Planck Institute for Brain Research)
- Gilles Laurent
(Max Planck Institute for Brain Research)
Abstract
The mammalian claustrum, owing to its widespread connectivity with other forebrain structures, has been hypothesized to mediate functions that range from decision-making to consciousness1. Here we report that a homologue of the claustrum, identified by single-cell transcriptomics and viral tracing of connectivity, also exists in a reptile—the Australian bearded dragon Pogona vitticeps. In Pogona, the claustrum underlies the generation of sharp waves during slow-wave sleep. The sharp waves, together with superimposed high-frequency ripples2, propagate to the entire neighbouring pallial dorsal ventricular ridge (DVR). Unilateral or bilateral lesions of the claustrum suppress the production of sharp-wave ripples during slow-wave sleep in a unilateral or bilateral manner, respectively, but do not affect the regular and rapidly alternating sleep rhythm that is characteristic of sleep in this species3. The claustrum is thus not involved in the generation of the sleep rhythm itself. Tract tracing revealed that the reptilian claustrum projects widely to a variety of forebrain areas, including the cortex, and that it receives converging inputs from, among others, areas of the mid- and hindbrain that are known to be involved in wake–sleep control in mammals4–6. Periodically modulating the concentration of serotonin in the claustrum, for example, caused a matching modulation of sharp-wave production there and in the neighbouring DVR. Using transcriptomic approaches, we also identified a claustrum in the turtle Trachemys scripta, a distant reptilian relative of lizards. The claustrum is therefore an ancient structure that was probably already present in the brain of the common vertebrate ancestor of reptiles and mammals. It may have an important role in the control of brain states owing to the ascending input it receives from the mid- and hindbrain, its widespread projections to the forebrain and its role in sharp-wave generation during slow-wave sleep.
Suggested Citation
Hiroaki Norimoto & Lorenz A. Fenk & Hsing-Hsi Li & Maria Antonietta Tosches & Tatiana Gallego-Flores & David Hain & Sam Reiter & Riho Kobayashi & Angeles Macias & Anja Arends & Michaela Klinkmann & Gi, 2020.
"A claustrum in reptiles and its role in slow-wave sleep,"
Nature, Nature, vol. 578(7795), pages 413-418, February.
Handle:
RePEc:nat:nature:v:578:y:2020:i:7795:d:10.1038_s41586-020-1993-6
DOI: 10.1038/s41586-020-1993-6
Download full text from publisher
As the access to this document is restricted, you may want to search for a different version of it.
Citations
Citations are extracted by the
CitEc Project, subscribe to its
RSS feed for this item.
Cited by:
- Guihua Xiao & Yeyi Cai & Yuanlong Zhang & Jingyu Xie & Lifan Wu & Hao Xie & Jiamin Wu & Qionghai Dai, 2024.
"Mesoscale neuronal granular trial variability in vivo illustrated by nonlinear recurrent network in silico,"
Nature Communications, Nature, vol. 15(1), pages 1-16, December.
- Gal Atlan & Noa Matosevich & Noa Peretz-Rivlin & Idit Marsh-Yvgi & Noam Zelinger & Eden Chen & Timna Kleinman & Noa Bleistein & Efrat Sheinbach & Maya Groysman & Yuval Nir & Ami Citri, 2024.
"Claustrum neurons projecting to the anterior cingulate restrict engagement during sleep and behavior,"
Nature Communications, Nature, vol. 15(1), pages 1-14, December.
- Layton Lamsam & Brett Gu & Mingli Liang & George Sun & Kamren J. Khan & Kevin N. Sheth & Lawrence J. Hirsch & Christopher Pittenger & Alfred P. Kaye & John H. Krystal & Eyiyemisi C. Damisah, 2024.
"The human claustrum tracks slow waves during sleep,"
Nature Communications, Nature, vol. 15(1), pages 1-12, December.
- David Morizet & Isabelle Foucher & Alessandro Alunni & Laure Bally-Cuif, 2024.
"Reconstruction of macroglia and adult neurogenesis evolution through cross-species single-cell transcriptomic analyses,"
Nature Communications, Nature, vol. 15(1), pages 1-15, December.
Corrections
All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:578:y:2020:i:7795:d:10.1038_s41586-020-1993-6. See general information about how to correct material in RePEc.
If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.
We have no bibliographic references for this item. You can help adding them by using this form .
If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.
For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .
Please note that corrections may take a couple of weeks to filter through
the various RePEc services.