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Microorganism microneedle micro-engine depth drug delivery

Author

Listed:
  • Bin Zheng

    (Tianjin University
    Tianjin Medical University)

  • Qiuya Li

    (Tianjin University)

  • Laiping Fang

    (Jinan University)

  • Xiaolu Cai

    (Huazhong University of Science and Technology)

  • Yan Liu

    (Harvard University)

  • Yanhong Duo

    (Harvard University)

  • Bowen Li

    (Tianjin University)

  • Zhengyu Wu

    (Tianjin University)

  • Boxi Shen

    (Tianjin University)

  • Yang Bai

    (Tianjin University
    Tianjin Medical University General Hospital)

  • Shi-Xiang Cheng

    (TANGYI Biomedicine (Tianjin) Co. Ltd (TBMed))

  • Xingcai Zhang

    (Stanford University)

Abstract

As a transdermal drug delivery method, microneedles offer minimal invasiveness, painlessness, and precise in-situ treatment. However, current microneedles rely on passive diffusion, leading to uncontrollable drug penetration. To overcome this, we developed a pneumatic microneedle patch that uses live Enterobacter aerogenes as microengines to actively control drug delivery. These microbes generate gas, driving drugs into deeper tissues, with adjustable glucose concentration allowing precise control over the process. Our results showed that this microorganism-powered system increases drug delivery depth by over 200%, reaching up to 1000 μm below the skin. In a psoriasis animal model, the technology effectively delivered calcitriol into subcutaneous tissues, offering rapid symptom relief. This innovation addresses the limitations of conventional microneedles, enhancing drug efficiency, transdermal permeability, and introducing a creative paradigm for on-demand controlled drug delivery.

Suggested Citation

  • Bin Zheng & Qiuya Li & Laiping Fang & Xiaolu Cai & Yan Liu & Yanhong Duo & Bowen Li & Zhengyu Wu & Boxi Shen & Yang Bai & Shi-Xiang Cheng & Xingcai Zhang, 2024. "Microorganism microneedle micro-engine depth drug delivery," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-53280-8
    DOI: 10.1038/s41467-024-53280-8
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    References listed on IDEAS

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    1. Xin Li & Yong Hu & Xingcai Zhang & Xiangyang Shi & Wolfgang J. Parak & Andrij Pich, 2024. "Transvascular transport of nanocarriers for tumor delivery," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    2. Omid Veiseh & Robert Langer, 2015. "A smart insulin patch," Nature, Nature, vol. 524(7563), pages 39-40, August.
    3. Wei Chen & Rui Tian & Can Xu & Bryant C. Yung & Guohao Wang & Yijing Liu & Qianqian Ni & Fuwu Zhang & Zijian Zhou & Jingjing Wang & Gang Niu & Ying Ma & Liwu Fu & Xiaoyuan Chen, 2017. "Microneedle-array patches loaded with dual mineralized protein/peptide particles for type 2 diabetes therapy," Nature Communications, Nature, vol. 8(1), pages 1-11, December.
    4. Bin Yang & Jilie Kong & Xueen Fang, 2022. "Programmable CRISPR-Cas9 microneedle patch for long-term capture and real-time monitoring of universal cell-free DNA," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    5. Gang He & Yashi Li & Muhammad Rizwan Younis & Lian-Hua Fu & Ting He & Shan Lei & Jing Lin & Peng Huang, 2022. "Synthetic biology-instructed transdermal microneedle patch for traceable photodynamic therapy," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    6. Ao Fang & Yifan Wang & Naiyu Guan & Yanming Zuo & Lingmin Lin & Binjie Guo & Aisheng Mo & Yile Wu & Xurong Lin & Wanxiong Cai & Xiangfeng Chen & Jingjia Ye & Zeinab Abdelrahman & Xiaodan Li & Hanyu Zh, 2023. "Author Correction: Porous microneedle patch with sustained delivery of extracellular vesicles mitigates severe spinal cord injury," Nature Communications, Nature, vol. 14(1), pages 1-1, December.
    7. Ao Fang & Yifan Wang & Naiyu Guan & Yanming Zuo & Lingmin Lin & Binjie Guo & Aisheng Mo & Yile Wu & Xurong Lin & Wanxiong Cai & Xiangfeng Chen & Jingjia Ye & Zeinab Abdelrahman & Xiaodan Li & Hanyu Zh, 2023. "Porous microneedle patch with sustained delivery of extracellular vesicles mitigates severe spinal cord injury," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    8. Shengqiang Chen & Yuanman Yu & Songqing Xie & Danna Liang & Wei Shi & Sizhen Chen & Guanglin Li & Wei Tang & Changsheng Liu & Qianjun He, 2023. "Local H2 release remodels senescence microenvironment for improved repair of injured bone," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    9. Ying Zhang & Shenqiang Wang & Yinxian Yang & Sheng Zhao & Jiahuan You & Junxia Wang & Jingwei Cai & Hao Wang & Jie Wang & Wei Zhang & Jicheng Yu & Chunmao Han & Yuqi Zhang & Zhen Gu, 2023. "Scarless wound healing programmed by core-shell microneedles," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    10. Penghe Zhao & Zhaokui Jin & Qian Chen & Tian Yang & Danyang Chen & Jin Meng & Xifeng Lu & Zhen Gu & Qianjun He, 2018. "Local generation of hydrogen for enhanced photothermal therapy," Nature Communications, Nature, vol. 9(1), pages 1-12, December.
    11. Jian Zeng & Xin’Ai Zhao & Zhe Liang & Inés Hidalgo & Michael Gebert & Pengfei Fan & Christian Wenzl & Sebastian G. Gornik & Jan U. Lohmann, 2023. "Nitric oxide controls shoot meristem activity via regulation of DNA methylation," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
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