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Photocatalytic glucose depletion and hydrogen generation for diabetic wound healing

Author

Listed:
  • Shengqiang Chen

    (Shenzhen University)

  • Yanxia Zhu

    (Shenzhen University Health Science Center)

  • Qingqing Xu

    (Shenzhen University)

  • Qi Jiang

    (Shenzhen University)

  • Danyang Chen

    (Shanghai Jiao Tong University)

  • Ting Chen

    (Shenzhen University)

  • Xishen Xu

    (Shenzhen University)

  • Zhaokui Jin

    (Shenzhen University)

  • Qianjun He

    (Shenzhen University
    Shanghai Jiao Tong University
    Shanghai Jiao Tong University)

Abstract

High-glucose microenvironment in the diabetic foot ulcer (DFU) causes excessive glycation and induces chronic inflammation, leading to the difficulty of DFU healing. Hydrogen-rich water bath can promote the healing of DFU in clinic by virtue of the anti-inflammatory effect of hydrogen molecules, but the long-term daily soaking counts against the formation of a scab and cannot change the high-glucose microenvironment, limiting the outcome of DFU therapy. In this work, photocatalytic therapy of diabetic wound is proposed for sustainable hydrogen generation and local glucose depletion by utilizing glucose in the high-glucose microenvironment as a sacrificial agent. Hydrogen-incorporated titanium oxide nanorods are developed to realize efficient visible light (VIS)-responsive photocatalysis for glucose depletion and hydrogen generation, achieving a high efficacy of diabetic wound healing. Mechanistically, local glucose depletion and hydrogen generation jointly attenuate the apoptosis of skin cells and promote their proliferation and migration by inhibiting the synthesis of advanced glycation end products and the expression of their receptors, respectively. The proposed VIS-photocatalytic strategy provides a solution for facile, safe and efficient treatment of DFU.

Suggested Citation

  • Shengqiang Chen & Yanxia Zhu & Qingqing Xu & Qi Jiang & Danyang Chen & Ting Chen & Xishen Xu & Zhaokui Jin & Qianjun He, 2022. "Photocatalytic glucose depletion and hydrogen generation for diabetic wound healing," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
  • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-33475-7
    DOI: 10.1038/s41467-022-33475-7
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    References listed on IDEAS

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    1. Penghe Zhao & Zhaokui Jin & Qian Chen & Tian Yang & Danyang Chen & Jin Meng & Xifeng Lu & Zhen Gu & Qianjun He, 2018. "Local generation of hydrogen for enhanced photothermal therapy," Nature Communications, Nature, vol. 9(1), pages 1-12, December.
    2. Wei-Lin Wan & Bo Tian & Yu-Jung Lin & Chiranjeevi Korupalli & Ming-Yen Lu & Qinghua Cui & Dehui Wan & Yen Chang & Hsing-Wen Sung, 2020. "Photosynthesis-inspired H2 generation using a chlorophyll-loaded liposomal nanoplatform to detect and scavenge excess ROS," Nature Communications, Nature, vol. 11(1), pages 1-9, December.
    3. Landong Li & Junqing Yan & Tuo Wang & Zhi-Jian Zhao & Jian Zhang & Jinlong Gong & Naijia Guan, 2015. "Sub-10 nm rutile titanium dioxide nanoparticles for efficient visible-light-driven photocatalytic hydrogen production," Nature Communications, Nature, vol. 6(1), pages 1-10, May.
    4. Bin Zhao & Yingshuai Wang & Xianxian Yao & Danyang Chen & Mingjian Fan & Zhaokui Jin & Qianjun He, 2021. "Photocatalysis-mediated drug-free sustainable cancer therapy using nanocatalyst," Nature Communications, Nature, vol. 12(1), pages 1-11, December.
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    Cited by:

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    2. Zhaokui Jin & Lingdong Jiang & Qianjun He, 2024. "Critical learning from industrial catalysis for nanocatalytic medicine," Nature Communications, Nature, vol. 15(1), pages 1-11, December.

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