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Local generation of hydrogen for enhanced photothermal therapy

Author

Listed:
  • Penghe Zhao

    (Shenzhen University)

  • Zhaokui Jin

    (Shenzhen University)

  • Qian Chen

    (University of California, Los Angeles
    University of California, Los Angeles
    University of North Carolina at Chapel Hill and North Carolina State University)

  • Tian Yang

    (Shenzhen University)

  • Danyang Chen

    (Shenzhen University)

  • Jin Meng

    (Shenzhen University)

  • Xifeng Lu

    (Shenzhen University)

  • Zhen Gu

    (University of California, Los Angeles
    University of California, Los Angeles
    University of North Carolina at Chapel Hill and North Carolina State University)

  • Qianjun He

    (Shenzhen University)

Abstract

By delivering the concept of clean hydrogen energy and green catalysis to the biomedical field, engineering of hydrogen-generating nanomaterials for treatment of major diseases holds great promise. Leveraging virtue of versatile abilities of Pd hydride nanomaterials in high/stable hydrogen storage, self-catalytic hydrogenation, near-infrared (NIR) light absorption and photothermal conversion, here we utilize the cubic PdH0.2 nanocrystals for tumour-targeted and photoacoustic imaging (PAI)-guided hydrogenothermal therapy of cancer. The synthesized PdH0.2 nanocrystals have exhibited high intratumoural accumulation capability, clear NIR-controlled hydrogen release behaviours, NIR-enhanced self-catalysis bio-reductivity, high NIR-photothermal effect and PAI performance. With these unique properties of PdH0.2 nanocrystals, synergetic hydrogenothermal therapy with limited systematic toxicity has been achieved by tumour-targeted delivery and PAI-guided NIR-controlled release of bio-reductive hydrogen as well as generation of heat. This hydrogenothermal approach has presented a cancer-selective strategy for synergistic cancer treatment.

Suggested Citation

  • Penghe Zhao & Zhaokui Jin & Qian Chen & Tian Yang & Danyang Chen & Jin Meng & Xifeng Lu & Zhen Gu & Qianjun He, 2018. "Local generation of hydrogen for enhanced photothermal therapy," Nature Communications, Nature, vol. 9(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-06630-2
    DOI: 10.1038/s41467-018-06630-2
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    Cited by:

    1. Shengqiang Chen & Yanxia Zhu & Qingqing Xu & Qi Jiang & Danyang Chen & Ting Chen & Xishen Xu & Zhaokui Jin & Qianjun He, 2022. "Photocatalytic glucose depletion and hydrogen generation for diabetic wound healing," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    2. Zhaokui Jin & Lingdong Jiang & Qianjun He, 2024. "Critical learning from industrial catalysis for nanocatalytic medicine," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    3. Nailin Yang & Fei Gong & Bo Liu & Yu Hao & Yu Chao & Huali Lei & Xiaoyuan Yang & Yuehan Gong & Xianwen Wang & Zhuang Liu & Liang Cheng, 2022. "Magnesium galvanic cells produce hydrogen and modulate the tumor microenvironment to inhibit cancer growth," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    4. Bin Zheng & Qiuya Li & Laiping Fang & Xiaolu Cai & Yan Liu & Yanhong Duo & Bowen Li & Zhengyu Wu & Boxi Shen & Yang Bai & Shi-Xiang Cheng & Xingcai Zhang, 2024. "Microorganism microneedle micro-engine depth drug delivery," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

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