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Microneedle-array patches loaded with dual mineralized protein/peptide particles for type 2 diabetes therapy

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  • Wei Chen

    (Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center
    National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH))

  • Rui Tian

    (National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH)
    Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University)

  • Can Xu

    (National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH))

  • Bryant C. Yung

    (National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH))

  • Guohao Wang

    (Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University)

  • Yijing Liu

    (National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH))

  • Qianqian Ni

    (National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH))

  • Fuwu Zhang

    (National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH))

  • Zijian Zhou

    (National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH)
    Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University)

  • Jingjing Wang

    (National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH))

  • Gang Niu

    (National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH))

  • Ying Ma

    (National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH))

  • Liwu Fu

    (Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center)

  • Xiaoyuan Chen

    (National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH))

Abstract

The delivery of therapeutic peptides for diabetes therapy is compromised by short half-lives of drugs with the consequent need for multiple daily injections that reduce patient compliance and increase treatment cost. In this study, we demonstrate a smart exendin-4 (Ex4) delivery device based on microneedle (MN)-array patches integrated with dual mineralized particles separately containing Ex4 and glucose oxidase (GOx). The dual mineralized particle-based system can specifically release Ex4 while immobilizing GOx as a result of the differential response to the microenvironment induced by biological stimuli. In this manner, the system enables glucose-responsive and closed-loop release to significantly improve Ex4 therapeutic performance. Moreover, integration of mineralized particles can enhance the mechanical strength of alginate-based MN by crosslinking to facilitate skin penetration, thus supporting painless and non-invasive transdermal administration. We believe this smart glucose-responsive Ex4 delivery holds great promise for type 2 diabetes therapy by providing safe, long-term, and on-demand Ex4 therapy.

Suggested Citation

  • Wei Chen & Rui Tian & Can Xu & Bryant C. Yung & Guohao Wang & Yijing Liu & Qianqian Ni & Fuwu Zhang & Zijian Zhou & Jingjing Wang & Gang Niu & Ying Ma & Liwu Fu & Xiaoyuan Chen, 2017. "Microneedle-array patches loaded with dual mineralized protein/peptide particles for type 2 diabetes therapy," Nature Communications, Nature, vol. 8(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_s41467-017-01764-1
    DOI: 10.1038/s41467-017-01764-1
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    Cited by:

    1. Yihang Wang & Zeka Chen & Brayden Davis & Will Lipman & Sicheng Xing & Lin Zhang & Tian Wang & Priyash Hafiz & Wanrong Xie & Zijie Yan & Zhili Huang & Juan Song & Wubin Bai, 2024. "Digital automation of transdermal drug delivery with high spatiotemporal resolution," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    2. Zhuo-Ran Yang & Huinan Suo & Jing-Wen Fan & Niannian Lv & Kehan Du & Teng Ma & Huimin Qin & Yan Li & Liu Yang & Nuoya Zhou & Hao Jiang & Juan Tao & Jintao Zhu, 2024. "Endogenous stimuli-responsive separating microneedles to inhibit hypertrophic scar through remodeling the pathological microenvironment," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    3. Gang He & Yashi Li & Muhammad Rizwan Younis & Lian-Hua Fu & Ting He & Shan Lei & Jing Lin & Peng Huang, 2022. "Synthetic biology-instructed transdermal microneedle patch for traceable photodynamic therapy," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    4. Bin Zheng & Qiuya Li & Laiping Fang & Xiaolu Cai & Yan Liu & Yanhong Duo & Bowen Li & Zhengyu Wu & Boxi Shen & Yang Bai & Shi-Xiang Cheng & Xingcai Zhang, 2024. "Microorganism microneedle micro-engine depth drug delivery," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

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