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Gut symbiont-derived sphingosine modulates vector competence in Aedes mosquitoes

Author

Listed:
  • Xiaomei Sun

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Yanhong Wang

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Fei Yuan

    (Chinese Academy of Sciences)

  • Yanan Zhang

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Xun Kang

    (Hainan Medical University)

  • Jian Sun

    (Chinese Academy of Sciences)

  • Pengcheng Wang

    (Chinese Academy of Sciences)

  • Tengfei Lu

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Fanny Sae Wang

    (Mahidol University)

  • Jinbao Gu

    (Southern Medical University)

  • Jinglin Wang

    (Yunnan Animal Science and Veterinary Institute)

  • Qianfeng Xia

    (Hainan Medical University)

  • Aihua Zheng

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Zhen Zou

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

Abstract

The main vectors of Zika virus (ZIKV) and dengue virus (DENV) are Aedes aegypti and Ae. albopictus, with Ae. aegypti being more competent. However, the underlying mechanisms remain unclear. Here, we find Ae. albopictus shows comparable vector competence to ZIKV/DENV with Ae. aegypti by blood-feeding after antibiotic treatment or intrathoracic injection. This suggests that midgut microbiota can influence vector competence. Enterobacter hormaechei_B17 (Eh_B17) is isolated from field-collected Ae. albopictus and conferred resistance to ZIKV/DENV infection in Ae. aegypti after gut-transplantation. Sphingosine, a metabolite secreted by Eh_B17, effectively suppresses ZIKV infection in both Ae. aegypti and cell cultures by blocking viral entry during the fusion step, with an IC50 of approximately 10 μM. A field survey reveals that Eh_B17 preferentially colonizes Ae. albopictus compared to Ae. aegypti. And field Ae. albopictus positive for Eh_B17 are more resistant to ZIKV infection. These findings underscore the potential of gut symbiotic bacteria, such as Eh_B17, to modulate the arbovirus vector competence of Aedes mosquitoes. As a natural antiviral agent, Eh_B17 holds promise as a potential candidate for blocking ZIKV/DENV transmission.

Suggested Citation

  • Xiaomei Sun & Yanhong Wang & Fei Yuan & Yanan Zhang & Xun Kang & Jian Sun & Pengcheng Wang & Tengfei Lu & Fanny Sae Wang & Jinbao Gu & Jinglin Wang & Qianfeng Xia & Aihua Zheng & Zhen Zou, 2024. "Gut symbiont-derived sphingosine modulates vector competence in Aedes mosquitoes," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-52566-1
    DOI: 10.1038/s41467-024-52566-1
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