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Wolbachia infections in natural Anopheles populations affect egg laying and negatively correlate with Plasmodium development

Author

Listed:
  • W. Robert Shaw

    (Harvard T.H. Chan School of Public Health)

  • Perrine Marcenac

    (Harvard T.H. Chan School of Public Health)

  • Lauren M. Childs

    (Center for Communicable Disease Dynamics, Harvard T.H. Chan School of Public Health
    Harvard T.H. Chan School of Public Health)

  • Caroline O. Buckee

    (Center for Communicable Disease Dynamics, Harvard T.H. Chan School of Public Health
    Harvard T.H. Chan School of Public Health)

  • Francesco Baldini

    (Institute of Biodiversity, Animal Health and Comparative Medicine, University of Glasgow)

  • Simon P. Sawadogo

    (Institut de Recherche en Sciences de la Santé/Centre Muraz)

  • Roch K. Dabiré

    (Institut de Recherche en Sciences de la Santé/Centre Muraz)

  • Abdoulaye Diabaté

    (Institut de Recherche en Sciences de la Santé/Centre Muraz)

  • Flaminia Catteruccia

    (Harvard T.H. Chan School of Public Health)

Abstract

The maternally inherited alpha-proteobacterium Wolbachia has been proposed as a tool to block transmission of devastating mosquito-borne infectious diseases like dengue and malaria. Here we study the reproductive manipulations induced by a recently identified Wolbachia strain that stably infects natural mosquito populations of a major malaria vector, Anopheles coluzzii, in Burkina Faso. We determine that these infections significantly accelerate egg laying but do not induce cytoplasmic incompatibility or sex-ratio distortion, two parasitic reproductive phenotypes that facilitate the spread of other Wolbachia strains within insect hosts. Analysis of 221 blood-fed A. coluzzii females collected from houses shows a negative correlation between the presence of Plasmodium parasites and Wolbachia infection. A mathematical model incorporating these results predicts that infection with these endosymbionts may reduce malaria prevalence in human populations. These data suggest that Wolbachia may be an important player in malaria transmission dynamics in Sub-Saharan Africa.

Suggested Citation

  • W. Robert Shaw & Perrine Marcenac & Lauren M. Childs & Caroline O. Buckee & Francesco Baldini & Simon P. Sawadogo & Roch K. Dabiré & Abdoulaye Diabaté & Flaminia Catteruccia, 2016. "Wolbachia infections in natural Anopheles populations affect egg laying and negatively correlate with Plasmodium development," Nature Communications, Nature, vol. 7(1), pages 1-7, September.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms11772
    DOI: 10.1038/ncomms11772
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    Cited by:

    1. Xiaomei Sun & Yanhong Wang & Fei Yuan & Yanan Zhang & Xun Kang & Jian Sun & Pengcheng Wang & Tengfei Lu & Fanny Sae Wang & Jinbao Gu & Jinglin Wang & Qianfeng Xia & Aihua Zheng & Zhen Zou, 2024. "Gut symbiont-derived sphingosine modulates vector competence in Aedes mosquitoes," Nature Communications, Nature, vol. 15(1), pages 1-16, December.

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