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Leucine aminopeptidase1 controls egg deposition and hatchability in male Aedes aegypti mosquitoes

Author

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  • Xiaomei Sun

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Xueli Wang

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Kai Shi

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Xiangyang Lyu

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Jian Sun

    (Chinese Academy of Sciences)

  • Alexander S. Raikhel

    (University of California)

  • Zhen Zou

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

Abstract

Aedes aegypti are vectors for several arboviruses infecting hundreds of millions of people annually. Controlling mosquito populations by regulating their reproduction is a potential strategy to minimize viral transmission in the absence of effective antiviral therapies or vaccines. Here, we demonstrate that leucine aminopeptidase1 (LAP1), detected by a SWATH-MS-based proteomic screen of female spermathecae, is a crucial determinant in mosquito population expansion. Mitochondrial defects and aberrant autophagy of sperm in LAP1 mutant males (LAP1−/−), prepared using CRISPR/Cas9 system, result in a reduction of reproduction in wild-type females that mated with them. The fitness of LAP1−/− males is strong enough to efficiently transmit genetic changes to mosquito populations through a low number of hatchable offspring. Thus, LAP1−/− males represent an opportunity to suppress mosquito populations and further studies should be undertaken to characterize LAP1’s suitability for gene drive usage.

Suggested Citation

  • Xiaomei Sun & Xueli Wang & Kai Shi & Xiangyang Lyu & Jian Sun & Alexander S. Raikhel & Zhen Zou, 2024. "Leucine aminopeptidase1 controls egg deposition and hatchability in male Aedes aegypti mosquitoes," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-023-44444-z
    DOI: 10.1038/s41467-023-44444-z
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    1. Xiaoying Zheng & Dongjing Zhang & Yongjun Li & Cui Yang & Yu Wu & Xiao Liang & Yongkang Liang & Xiaoling Pan & Linchao Hu & Qiang Sun & Xiaohua Wang & Yingyang Wei & Jian Zhu & Wei Qian & Ziqiang Yan , 2019. "Incompatible and sterile insect techniques combined eliminate mosquitoes," Nature, Nature, vol. 572(7767), pages 56-61, August.
    2. Ming Li & Ting Yang & Michelle Bui & Stephanie Gamez & Tyler Wise & Nikolay P. Kandul & Junru Liu & Lenissa Alcantara & Haena Lee & Jyotheeswara R. Edula & Robyn Raban & Yinpeng Zhan & Yijin Wang & Ni, 2021. "Suppressing mosquito populations with precision guided sterile males," Nature Communications, Nature, vol. 12(1), pages 1-10, December.
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    Cited by:

    1. Xiaomei Sun & Yanhong Wang & Fei Yuan & Yanan Zhang & Xun Kang & Jian Sun & Pengcheng Wang & Tengfei Lu & Fanny Sae Wang & Jinbao Gu & Jinglin Wang & Qianfeng Xia & Aihua Zheng & Zhen Zou, 2024. "Gut symbiont-derived sphingosine modulates vector competence in Aedes mosquitoes," Nature Communications, Nature, vol. 15(1), pages 1-16, December.

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