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Successful establishment of Wolbachia in Aedes populations to suppress dengue transmission

Author

Listed:
  • A. A. Hoffmann

    (Bio21 Institute, The University of Melbourne, Victoria 3010, Australia)

  • B. L. Montgomery

    (School of Biological Sciences, The University of Queensland)

  • J. Popovici

    (School of Biological Sciences, The University of Queensland
    School of Biological Sciences, Monash University, Victoria 3800, Australia)

  • I. Iturbe-Ormaetxe

    (School of Biological Sciences, The University of Queensland
    School of Biological Sciences, Monash University, Victoria 3800, Australia)

  • P. H. Johnson

    (School of Public Health and Tropical Medicine and Rehabilitative Sciences, James Cook University)

  • F. Muzzi

    (School of Biological Sciences, The University of Queensland)

  • M. Greenfield

    (School of Biological Sciences, The University of Queensland)

  • M. Durkan

    (School of Biological Sciences, The University of Queensland)

  • Y. S. Leong

    (School of Biological Sciences, The University of Queensland)

  • Y. Dong

    (School of Biological Sciences, The University of Queensland
    School of Biological Sciences, Monash University, Victoria 3800, Australia)

  • H. Cook

    (School of Biological Sciences, The University of Queensland)

  • J. Axford

    (Bio21 Institute, The University of Melbourne, Victoria 3010, Australia)

  • A. G. Callahan

    (Bio21 Institute, The University of Melbourne, Victoria 3010, Australia)

  • N. Kenny

    (School of Biological Sciences, The University of Queensland
    School of Biological Sciences, Monash University, Victoria 3800, Australia)

  • C. Omodei

    (School of Public Health and Tropical Medicine and Rehabilitative Sciences, James Cook University)

  • E. A. McGraw

    (School of Biological Sciences, The University of Queensland
    School of Biological Sciences, Monash University, Victoria 3800, Australia)

  • P. A. Ryan

    (School of Biological Sciences, The University of Queensland
    School of Biological Sciences, Monash University, Victoria 3800, Australia
    Queensland Institute of Medical Research, Post Office Royal Brisbane Hospital)

  • S. A. Ritchie

    (School of Public Health and Tropical Medicine and Rehabilitative Sciences, James Cook University)

  • M. Turelli

    (University of California)

  • S. L. O’Neill

    (School of Biological Sciences, The University of Queensland
    School of Biological Sciences, Monash University, Victoria 3800, Australia)

Abstract

Wolbachia used to counter dengue fever The mosquito-borne viral disease dengue fever is an increasing problem in tropical and subtropical regions. Traditional control measures aimed at reducing populations of the main transmission vector, Aedes aegypti, have had little success. Two papers in this issue report an alternative approach to mosquito population control using the bacterium Wolbachia pipientis, natural insect symbionts that facilitate their own transmission through a process called cytoplasmic incompatibility. In the first paper, Scott O'Neill and colleagues describe a Wolbachia strain derived from fruitflies that significantly reduces dengue virus carriage in mosquitoes without imposing a fitness cost. In the second paper, they demonstrate in a controlled field trial that the release of colonized mosquitoes leads to successful invasion of natural mosquito populations. These results suggest a viable strategy to control dengue fever.

Suggested Citation

  • A. A. Hoffmann & B. L. Montgomery & J. Popovici & I. Iturbe-Ormaetxe & P. H. Johnson & F. Muzzi & M. Greenfield & M. Durkan & Y. S. Leong & Y. Dong & H. Cook & J. Axford & A. G. Callahan & N. Kenny & , 2011. "Successful establishment of Wolbachia in Aedes populations to suppress dengue transmission," Nature, Nature, vol. 476(7361), pages 454-457, August.
    • Handle: RePEc:nat:nature:v:476:y:2011:i:7361:d:10.1038_nature10356
    DOI: 10.1038/nature10356
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    Cited by:

    1. Xiaomei Sun & Yanhong Wang & Fei Yuan & Yanan Zhang & Xun Kang & Jian Sun & Pengcheng Wang & Tengfei Lu & Fanny Sae Wang & Jinbao Gu & Jinglin Wang & Qianfeng Xia & Aihua Zheng & Zhen Zou, 2024. "Gut symbiont-derived sphingosine modulates vector competence in Aedes mosquitoes," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    2. Kristina K. Gonzales & Immo A. Hansen, 2016. "Artificial Diets for Mosquitoes," IJERPH, MDPI, vol. 13(12), pages 1-13, December.
    3. Lijie Chang & Yantao Shi & Bo Zheng, 2021. "Existence and Uniqueness of Nontrivial Periodic Solutions to a Discrete Switching Model," Mathematics, MDPI, vol. 9(19), pages 1-13, September.
    4. Ayu Rahayu & Utari Saraswati & Endah Supriyati & Dian Aruni Kumalawati & Rio Hermantara & Anwar Rovik & Edwin Widyanto Daniwijaya & Iva Fitriana & Sigit Setyawan & Riris Andono Ahmad & Dwi Satria Ward, 2019. "Prevalence and Distribution of Dengue Virus in Aedes aegypti in Yogyakarta City before Deployment of Wolbachia Infected Aedes aegypti," IJERPH, MDPI, vol. 16(10), pages 1-12, May.
    5. Martin Foureaux Koppensteiner & Lívia Menezes, 2024. "Maternal Dengue and Health Outcomes of Children," American Economic Journal: Applied Economics, American Economic Association, vol. 16(2), pages 530-553, April.
    6. Zhongcai Zhu & Yantao Shi & Rong Yan & Linchao Hu, 2022. "Periodic Orbits of a Mosquito Suppression Model Based on Sterile Mosquitoes," Mathematics, MDPI, vol. 10(3), pages 1-21, January.
    7. Rachel Lowe & Christovam Barcellos & Patrícia Brasil & Oswaldo G. Cruz & Nildimar Alves Honório & Hannah Kuper & Marilia Sá Carvalho, 2018. "The Zika Virus Epidemic in Brazil: From Discovery to Future Implications," IJERPH, MDPI, vol. 15(1), pages 1-18, January.
    8. Philipp Walch & Petr Broz, 2024. "Viral-bacterial co-infections screen in vitro reveals molecular processes affecting pathogen proliferation and host cell viability," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    9. Tiago França Melo De Lima & Raquel Martins Lana & Tiago Garcia De Senna Carneiro & Cláudia Torres Codeço & Gabriel Souza Machado & Lucas Saraiva Ferreira & Líliam César De Castro Medeiros & Clodoveu A, 2016. "DengueME: A Tool for the Modeling and Simulation of Dengue Spatiotemporal Dynamics," IJERPH, MDPI, vol. 13(9), pages 1-21, September.
    10. Turelli, Michael & Barton, Nicholas H., 2017. "Deploying dengue-suppressing Wolbachia : Robust models predict slow but effective spatial spread in Aedes aegypti," Theoretical Population Biology, Elsevier, vol. 115(C), pages 45-60.
    11. Li Ting Soh & Zoe Ong & Kathryn Vasquez & Irene Chen & Xiaoxi Li & Weixin Niah & Chitra Panchapakesan & Anita Sheldenkar & Shuzhen Sim & Lee Ching Ng & May O. Lwin, 2021. "A Household-Based Survey to Understand Factors Influencing Awareness, Attitudes and Knowledge towards Wolbachia-Aedes Technology," IJERPH, MDPI, vol. 18(22), pages 1-16, November.
    12. Li, Yazhi & Wang, Yan & Liu, Lili, 2023. "Optimal control of dengue vector based on a reaction–diffusion model," Mathematics and Computers in Simulation (MATCOM), Elsevier, vol. 203(C), pages 250-270.
    13. Vanessa M. Macias & Johanna R. Ohm & Jason L. Rasgon, 2017. "Gene Drive for Mosquito Control: Where Did It Come from and Where Are We Headed?," IJERPH, MDPI, vol. 14(9), pages 1-30, September.
    14. Auliya A. Suwantika & Angga P. Kautsar & Woro Supadmi & Neily Zakiyah & Rizky Abdulah & Mohammad Ali & Maarten J. Postma, 2020. "Cost-Effectiveness of Dengue Vaccination in Indonesia: Considering Integrated Programs with Wolbachia -Infected Mosquitos and Health Education," IJERPH, MDPI, vol. 17(12), pages 1-15, June.
    15. Yijie Li & Zhiming Guo, 2022. "Wolbachia Invasion Dynamics by Integrodifference Equations," Mathematics, MDPI, vol. 10(22), pages 1-13, November.
    16. Xingtong Liu & Yuanshun Tan & Bo Zheng, 2022. "Dynamic Behavior of an Interactive Mosquito Model under Stochastic Interference," Mathematics, MDPI, vol. 10(13), pages 1-18, June.

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