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Incompatible and sterile insect techniques combined eliminate mosquitoes

Author

Listed:
  • Xiaoying Zheng

    (Sun Yat-sen University–Michigan State University Joint Center of Vector Control for Tropical Diseases, Zhongshan School of Medicine, Sun Yat-sen University)

  • Dongjing Zhang

    (Sun Yat-sen University–Michigan State University Joint Center of Vector Control for Tropical Diseases, Zhongshan School of Medicine, Sun Yat-sen University
    Vienna International Centre)

  • Yongjun Li

    (Sun Yat-sen University–Michigan State University Joint Center of Vector Control for Tropical Diseases, Zhongshan School of Medicine, Sun Yat-sen University
    Guangzhou Wolbaki Biotech Co., Ltd)

  • Cui Yang

    (Sun Yat-sen University–Michigan State University Joint Center of Vector Control for Tropical Diseases, Zhongshan School of Medicine, Sun Yat-sen University
    Guangzhou Wolbaki Biotech Co., Ltd)

  • Yu Wu

    (Sun Yat-sen University–Michigan State University Joint Center of Vector Control for Tropical Diseases, Zhongshan School of Medicine, Sun Yat-sen University)

  • Xiao Liang

    (Michigan State University)

  • Yongkang Liang

    (Sun Yat-sen University–Michigan State University Joint Center of Vector Control for Tropical Diseases, Zhongshan School of Medicine, Sun Yat-sen University
    Guangzhou Wolbaki Biotech Co., Ltd)

  • Xiaoling Pan

    (Michigan State University
    Hunan Normal University)

  • Linchao Hu

    (Sun Yat-sen University–Michigan State University Joint Center of Vector Control for Tropical Diseases, Zhongshan School of Medicine, Sun Yat-sen University)

  • Qiang Sun

    (Sun Yat-sen University–Michigan State University Joint Center of Vector Control for Tropical Diseases, Zhongshan School of Medicine, Sun Yat-sen University
    Michigan State University)

  • Xiaohua Wang

    (Guangzhou Wolbaki Biotech Co., Ltd)

  • Yingyang Wei

    (Guangzhou Wolbaki Biotech Co., Ltd)

  • Jian Zhu

    (Guangzhou Wolbaki Biotech Co., Ltd)

  • Wei Qian

    (Guangzhou Wolbaki Biotech Co., Ltd)

  • Ziqiang Yan

    (Guangzhou Center for Disease Control and Prevention)

  • Andrew G. Parker

    (Vienna International Centre)

  • Jeremie R. L. Gilles

    (Vienna International Centre)

  • Kostas Bourtzis

    (Vienna International Centre)

  • Jérémy Bouyer

    (Vienna International Centre)

  • Moxun Tang

    (Michigan State University)

  • Bo Zheng

    (Guangzhou University)

  • Jianshe Yu

    (Guangzhou University)

  • Julian Liu

    (Guangzhou Wolbaki Biotech Co., Ltd)

  • Jiajia Zhuang

    (Sun Yat-sen University–Michigan State University Joint Center of Vector Control for Tropical Diseases, Zhongshan School of Medicine, Sun Yat-sen University)

  • Zhigang Hu

    (Guangzhou Center for Disease Control and Prevention)

  • Meichun Zhang

    (Sun Yat-sen University–Michigan State University Joint Center of Vector Control for Tropical Diseases, Zhongshan School of Medicine, Sun Yat-sen University)

  • Jun-Tao Gong

    (Nanjing Agricultural University)

  • Xiao-Yue Hong

    (Nanjing Agricultural University)

  • Zhoubing Zhang

    (Guangzhou Center for Disease Control and Prevention)

  • Lifeng Lin

    (Guangdong Provincial Center for Disease Control and Prevention)

  • Qiyong Liu

    (National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention)

  • Zhiyong Hu

    (Guangzhou University)

  • Zhongdao Wu

    (Sun Yat-sen University–Michigan State University Joint Center of Vector Control for Tropical Diseases, Zhongshan School of Medicine, Sun Yat-sen University)

  • Luke Anthony Baton

    (Michigan State University)

  • Ary A. Hoffmann

    (University of Melbourne)

  • Zhiyong Xi

    (Sun Yat-sen University–Michigan State University Joint Center of Vector Control for Tropical Diseases, Zhongshan School of Medicine, Sun Yat-sen University
    Guangzhou Wolbaki Biotech Co., Ltd
    Michigan State University)

Abstract

The radiation-based sterile insect technique (SIT) has successfully suppressed field populations of several insect pest species, but its effect on mosquito vector control has been limited. The related incompatible insect technique (IIT)—which uses sterilization caused by the maternally inherited endosymbiotic bacteria Wolbachia—is a promising alternative, but can be undermined by accidental release of females infected with the same Wolbachia strain as the released males. Here we show that combining incompatible and sterile insect techniques (IIT–SIT) enables near elimination of field populations of the world’s most invasive mosquito species, Aedes albopictus. Millions of factory-reared adult males with an artificial triple-Wolbachia infection were released, with prior pupal irradiation of the released mosquitoes to prevent unintentionally released triply infected females from successfully reproducing in the field. This successful field trial demonstrates the feasibility of area-wide application of combined IIT–SIT for mosquito vector control.

Suggested Citation

  • Xiaoying Zheng & Dongjing Zhang & Yongjun Li & Cui Yang & Yu Wu & Xiao Liang & Yongkang Liang & Xiaoling Pan & Linchao Hu & Qiang Sun & Xiaohua Wang & Yingyang Wei & Jian Zhu & Wei Qian & Ziqiang Yan , 2019. "Incompatible and sterile insect techniques combined eliminate mosquitoes," Nature, Nature, vol. 572(7767), pages 56-61, August.
    • Handle: RePEc:nat:nature:v:572:y:2019:i:7767:d:10.1038_s41586-019-1407-9
    DOI: 10.1038/s41586-019-1407-9
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    Citations

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    Cited by:

    1. Xiaomei Sun & Yanhong Wang & Fei Yuan & Yanan Zhang & Xun Kang & Jian Sun & Pengcheng Wang & Tengfei Lu & Fanny Sae Wang & Jinbao Gu & Jinglin Wang & Qianfeng Xia & Aihua Zheng & Zhen Zou, 2024. "Gut symbiont-derived sphingosine modulates vector competence in Aedes mosquitoes," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    2. Haramboure, Marion & Labbé, Pierrick & Baldet, Thierry & Damiens, David & Gouagna, Louis Clément & Bouyer, Jérémy & Tran, Annelise, 2020. "Modelling the control of Aedes albopictus mosquitoes based on sterile males release techniques in a tropical environment," Ecological Modelling, Elsevier, vol. 424(C).
    3. Lijie Chang & Yantao Shi & Bo Zheng, 2021. "Existence and Uniqueness of Nontrivial Periodic Solutions to a Discrete Switching Model," Mathematics, MDPI, vol. 9(19), pages 1-13, September.
    4. Zhongcai Zhu & Yantao Shi & Rong Yan & Linchao Hu, 2022. "Periodic Orbits of a Mosquito Suppression Model Based on Sterile Mosquitoes," Mathematics, MDPI, vol. 10(3), pages 1-21, January.
    5. Qiming Huang & Lijie Chang & Zhaowang Zhang & Bo Zheng, 2023. "Global Dynamics for Competition between Two Wolbachia Strains with Bidirectional Cytoplasmic Incompatibility," Mathematics, MDPI, vol. 11(7), pages 1-21, April.
    6. Dongjing Zhang & Hamidou Maiga & Yongjun Li & Mame Thierno Bakhoum & Gang Wang & Yan Sun & David Damiens & Wadaka Mamai & Nanwintoum Séverin Bimbilé Somda & Thomas Wallner & Odet Bueno-Masso & Claudia, 2024. "Mating harassment may boost the effectiveness of the sterile insect technique for Aedes mosquitoes," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    7. Chloé Hérault & Thomas Pihl & Bruno Hudry, 2024. "Cellular sex throughout the organism underlies somatic sexual differentiation," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    8. Dan Wen & Limin S. Ding & Yanan Zhang & Xiaoye Li & Xing Zhang & Fei Yuan & Tongbiao Zhao & Aihua Zheng, 2022. "Suppression of flavivirus transmission from animal hosts to mosquitoes with a mosquito-delivered vaccine," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    9. Yijie Li & Zhiming Guo, 2022. "Wolbachia Invasion Dynamics by Integrodifference Equations," Mathematics, MDPI, vol. 10(22), pages 1-13, November.
    10. Xiaomei Sun & Xueli Wang & Kai Shi & Xiangyang Lyu & Jian Sun & Alexander S. Raikhel & Zhen Zou, 2024. "Leucine aminopeptidase1 controls egg deposition and hatchability in male Aedes aegypti mosquitoes," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    11. Xingtong Liu & Yuanshun Tan & Bo Zheng, 2022. "Dynamic Behavior of an Interactive Mosquito Model under Stochastic Interference," Mathematics, MDPI, vol. 10(13), pages 1-18, June.

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