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Administration of anti-HIV-1 broadly neutralizing monoclonal antibodies with increased affinity to Fcγ receptors during acute SHIVAD8-EO infection

Author

Listed:
  • Joana Dias

    (National Institutes of Health)

  • Giulia Fabozzi

    (National Institutes of Health)

  • Slim Fourati

    (Emory University)

  • Xuejun Chen

    (National Institutes of Health)

  • Cuiping Liu

    (National Institutes of Health)

  • David R. Ambrozak

    (National Institutes of Health)

  • Amy Ransier

    (National Institutes of Health)

  • Farida Laboune

    (National Institutes of Health)

  • Jianfei Hu

    (National Institutes of Health)

  • Wei Shi

    (National Institutes of Health)

  • Kylie March

    (National Institutes of Health)

  • Anna A. Maximova

    (National Institutes of Health)

  • Stephen D. Schmidt

    (National Institutes of Health)

  • Jakob Samsel

    (National Institutes of Health
    George Washington University)

  • Chloe A. Talana

    (National Institutes of Health)

  • Keenan Ernste

    (National Institutes of Health)

  • Sung Hee Ko

    (National Institutes of Health)

  • Margaret E. Lucas

    (National Institutes of Health)

  • Pierce E. Radecki

    (National Institutes of Health)

  • Kristin L. Boswell

    (National Institutes of Health)

  • Yoshiaki Nishimura

    (National Institutes of Health)

  • John-Paul Todd

    (National Institutes of Health)

  • Malcolm A. Martin

    (National Institutes of Health)

  • Constantinos Petrovas

    (National Institutes of Health)

  • Eli A. Boritz

    (National Institutes of Health)

  • Nicole A. Doria-Rose

    (National Institutes of Health)

  • Daniel C. Douek

    (National Institutes of Health)

  • Rafick-Pierre Sékaly

    (Emory University)

  • Jeffrey D. Lifson

    (Frederick National Laboratory for Cancer Research)

  • Mangaiarkarasi Asokan

    (National Institutes of Health)

  • Lucio Gama

    (National Institutes of Health)

  • John R. Mascola

    (ModeX Therapeutics)

  • Amarendra Pegu

    (National Institutes of Health)

  • Richard A. Koup

    (National Institutes of Health)

Abstract

Anti-HIV-1 broadly neutralizing antibodies (bNAbs) have the dual potential of mediating virus neutralization and antiviral effector functions through their Fab and Fc domains, respectively. So far, bNAbs with enhanced Fc effector functions in vitro have only been tested in NHPs during chronic simian-HIV (SHIV) infection. Here, we investigate the effects of administering in acute SHIVAD8-EO infection either wild-type (WT) bNAbs or bNAbs carrying the S239D/I332E/A330L (DEL) mutation, which increases binding to FcγRs. Emergence of virus in plasma and lymph nodes (LNs) was delayed by bNAb treatment and occurred earlier in monkeys given DEL bNAbs than in those given WT bNAbs, consistent with faster clearance of DEL bNAbs from plasma. DEL bNAb-treated monkeys had higher levels of circulating virus-specific IFNγ single-producing CD8+ CD69+ T cells than the other groups. In LNs, WT bNAbs were evenly distributed between follicular and extrafollicular areas, but DEL bNAbs predominated in the latter. At week 8 post-challenge, LN monocytes and NK cells from DEL bNAb-treated monkeys upregulated proinflammatory signaling pathways and LN T cells downregulated TNF signaling via NF-κB. Overall, bNAbs with increased affinity to FcγRs shape innate and adaptive cellular immunity, which may be important to consider in future strategies of passive bNAb therapy.

Suggested Citation

  • Joana Dias & Giulia Fabozzi & Slim Fourati & Xuejun Chen & Cuiping Liu & David R. Ambrozak & Amy Ransier & Farida Laboune & Jianfei Hu & Wei Shi & Kylie March & Anna A. Maximova & Stephen D. Schmidt &, 2024. "Administration of anti-HIV-1 broadly neutralizing monoclonal antibodies with increased affinity to Fcγ receptors during acute SHIVAD8-EO infection," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
  • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-51848-y
    DOI: 10.1038/s41467-024-51848-y
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