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Early antibody therapy can induce long-lasting immunity to SHIV

Author

Listed:
  • Yoshiaki Nishimura

    (Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health)

  • Rajeev Gautam

    (Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health)

  • Tae-Wook Chun

    (Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health)

  • Reza Sadjadpour

    (Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health)

  • Kathryn E. Foulds

    (Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health)

  • Masashi Shingai

    (Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health)

  • Florian Klein

    (Institute of Virology, University of Cologne
    Center for Molecular Medicine Cologne (CMMC), University of Cologne)

  • Anna Gazumyan

    (Laboratory of Molecular Immunology, The Rockefeller University)

  • Jovana Golijanin

    (Laboratory of Molecular Immunology, The Rockefeller University)

  • Mitzi Donaldson

    (Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health)

  • Olivia K. Donau

    (Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health)

  • Ronald J. Plishka

    (Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health)

  • Alicia Buckler-White

    (Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health)

  • Michael S. Seaman

    (Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center)

  • Jeffrey D. Lifson

    (AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research)

  • Richard A. Koup

    (Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health)

  • Anthony S. Fauci

    (Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health)

  • Michel C. Nussenzweig

    (Laboratory of Molecular Immunology, The Rockefeller University
    Howard Hughes Medical Institute, The Rockefeller University)

  • Malcolm A. Martin

    (Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health)

Abstract

Early administration of broadly neutralizing antibodies in a macaque SHIV infection model is associated with very low levels of persistent viraemia, which leads to the establishment of T-cell immunity and resultant long-term infection control.

Suggested Citation

  • Yoshiaki Nishimura & Rajeev Gautam & Tae-Wook Chun & Reza Sadjadpour & Kathryn E. Foulds & Masashi Shingai & Florian Klein & Anna Gazumyan & Jovana Golijanin & Mitzi Donaldson & Olivia K. Donau & Rona, 2017. "Early antibody therapy can induce long-lasting immunity to SHIV," Nature, Nature, vol. 543(7646), pages 559-563, March.
    • Handle: RePEc:nat:nature:v:543:y:2017:i:7646:d:10.1038_nature21435
    DOI: 10.1038/nature21435
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    Citations

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    Cited by:

    1. Joana Dias & Giulia Fabozzi & Slim Fourati & Xuejun Chen & Cuiping Liu & David R. Ambrozak & Amy Ransier & Farida Laboune & Jianfei Hu & Wei Shi & Kylie March & Anna A. Maximova & Stephen D. Schmidt &, 2024. "Administration of anti-HIV-1 broadly neutralizing monoclonal antibodies with increased affinity to Fcγ receptors during acute SHIVAD8-EO infection," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    2. Christoph Kreer & Cosimo Lupo & Meryem S. Ercanoglu & Lutz Gieselmann & Natanael Spisak & Jan Grossbach & Maike Schlotz & Philipp Schommers & Henning Gruell & Leona Dold & Andreas Beyer & Armita Nourm, 2023. "Probabilities of developing HIV-1 bNAb sequence features in uninfected and chronically infected individuals," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    3. Caroline Passaes & Delphine Desjardins & Anaïs Chapel & Valérie Monceaux & Julien Lemaitre & Adeline Mélard & Federico Perdomo-Celis & Cyril Planchais & Maël Gourvès & Nastasia Dimant & Annie David & , 2024. "Early antiretroviral therapy favors post-treatment SIV control associated with the expansion of enhanced memory CD8+ T-cells," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    4. Miriam Rosás-Umbert & Jesper D. Gunst & Marie H. Pahus & Rikke Olesen & Mariane Schleimann & Paul W. Denton & Victor Ramos & Adam Ward & Natalie N. Kinloch & Dennis C. Copertino & Tuixent Escribà & An, 2022. "Administration of broadly neutralizing anti-HIV-1 antibodies at ART initiation maintains long-term CD8+ T cell immunity," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    5. Daniel B. Reeves & Bryan T. Mayer & Allan C. deCamp & Yunda Huang & Bo Zhang & Lindsay N. Carpp & Craig A. Magaret & Michal Juraska & Peter B. Gilbert & David C. Montefiori & Katharine J. Bar & E. Fab, 2023. "High monoclonal neutralization titers reduced breakthrough HIV-1 viral loads in the Antibody Mediated Prevention trials," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    6. Victoria E. K. Walker-Sperling & Noe B. Mercado & Abishek Chandrashekar & Erica N. Borducchi & Jinyan Liu & Joseph P. Nkolola & Mark Lewis & Jeffrey P. Murry & Yunling Yang & Romas Geleziunas & Merlin, 2022. "Therapeutic efficacy of combined active and passive immunization in ART-suppressed, SHIV-infected rhesus macaques," Nature Communications, Nature, vol. 13(1), pages 1-8, December.

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