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Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals

Author

Listed:
  • Johannes F. Scheid

    (Laboratory of Molecular Immunology,
    Charite Universitaetsmedizin)

  • Hugo Mouquet

    (Laboratory of Molecular Immunology,)

  • Niklas Feldhahn

    (Laboratory of Molecular Immunology,)

  • Michael S. Seaman

    (Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA)

  • Klara Velinzon

    (Laboratory of Molecular Immunology,)

  • John Pietzsch

    (Laboratory of Molecular Immunology,
    Institute of Chemistry and Biochemistry, Freie Universität Berlin)

  • Rene G. Ott

    (Laboratory of Molecular Genetics and Immunology,)

  • Robert M. Anthony

    (Laboratory of Molecular Genetics and Immunology,)

  • Henry Zebroski

    (Proteomics Resource Center,)

  • Arlene Hurley

    (Rockefeller University Hospital, and,)

  • Adhuna Phogat

    (Vaccine Research Center, and,)

  • Bimal Chakrabarti

    (Vaccine Research Center, and,)

  • Yuxing Li

    (Vaccine Research Center, and,)

  • Mark Connors

    (Laboratory of Immunoregulation, National Institutes of Allergy and Infectious Diseases, National Institutes of Health Bethesda, Maryland 20892, USA)

  • Florencia Pereyra

    (Partners AIDS Research Center, Mass General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA)

  • Bruce D. Walker

    (Partners AIDS Research Center, Mass General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA)

  • Hedda Wardemann

    (Max Planck Institute for Infection Biology)

  • David Ho

    (Aaron Diamond Aids Research Center
    New York)

  • Richard T. Wyatt

    (Vaccine Research Center, and,)

  • John R. Mascola

    (Vaccine Research Center, and,)

  • Jeffrey V. Ravetch

    (Laboratory of Molecular Genetics and Immunology,)

  • Michel C. Nussenzweig

    (Laboratory of Molecular Immunology,
    Howard Hughes Medical Institute, The Rockefeller University, New York, New York 10065, USA)

Abstract

Multiple antibodies fight HIV Serologic memory is an important factor in long-term vaccine efficacy, but there is little understanding of the antibodies produced by memory B cells in individuals infected with important human pathogens such as HIV. To examine the memory antibody response to HIV, Scheid et al. cloned more than 500 antibodies from HIV-specific memory B cells from six HIV-infected patients with high serum titres of broadly neutralizing antibodies. The B-cell memory response to HIV in these patients was composed of up to 50 independent expanded B clones expressing a heterogeneous collection of antibodies to different viral epitopes, several of which may be important for broad HIV neutralization and effective vaccination.

Suggested Citation

  • Johannes F. Scheid & Hugo Mouquet & Niklas Feldhahn & Michael S. Seaman & Klara Velinzon & John Pietzsch & Rene G. Ott & Robert M. Anthony & Henry Zebroski & Arlene Hurley & Adhuna Phogat & Bimal Chak, 2009. "Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals," Nature, Nature, vol. 458(7238), pages 636-640, April.
    • Handle: RePEc:nat:nature:v:458:y:2009:i:7238:d:10.1038_nature07930
    DOI: 10.1038/nature07930
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    Cited by:

    1. Luis M. Molinos-Albert & Valérie Lorin & Valérie Monceaux & Sylvie Orr & Asma Essat & Jérémy Dufloo & Olivier Schwartz & Christine Rouzioux & Laurence Meyer & Laurent Hocqueloux & Asier Sáez-Cirión & , 2022. "Transient viral exposure drives functionally-coordinated humoral immune responses in HIV-1 post-treatment controllers," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    2. Cyril Planchais & Luis M. Molinos-Albert & Pierre Rosenbaum & Thierry Hieu & Alexia Kanyavuz & Dominique Clermont & Thierry Prazuck & Laurent Lefrou & Jordan D. Dimitrov & Sophie Hüe & Laurent Hocquel, 2023. "HIV-1 treatment timing shapes the human intestinal memory B-cell repertoire to commensal bacteria," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    3. Nicole A Doria-Rose & Han R Altae-Tran & Ryan S Roark & Stephen D Schmidt & Matthew S Sutton & Mark K Louder & Gwo-Yu Chuang & Robert T Bailer & Valerie Cortez & Rui Kong & Krisha McKee & Sijy O’Dell , 2017. "Mapping Polyclonal HIV-1 Antibody Responses via Next-Generation Neutralization Fingerprinting," PLOS Pathogens, Public Library of Science, vol. 13(1), pages 1-29, January.
    4. Steven Schulz & Sébastien Boyer & Matteo Smerlak & Simona Cocco & Rémi Monasson & Clément Nizak & Olivier Rivoire, 2021. "Parameters and determinants of responses to selection in antibody libraries," PLOS Computational Biology, Public Library of Science, vol. 17(3), pages 1-24, March.
    5. Steve Lu & Austin K. Mattox & P. Aitana Azurmendi & Ilias Christodoulou & Katharine M. Wright & Maria Popoli & Zan Chen & Surojit Sur & Yana Li & Challice L. Bonifant & Chetan Bettegowda & Nickolas Pa, 2023. "The rapid and highly parallel identification of antibodies with defined biological activities by SLISY," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    6. Anna Hake & Nico Pfeifer, 2017. "Prediction of HIV-1 sensitivity to broadly neutralizing antibodies shows a trend towards resistance over time," PLOS Computational Biology, Public Library of Science, vol. 13(10), pages 1-23, October.
    7. Joana Dias & Giulia Fabozzi & Slim Fourati & Xuejun Chen & Cuiping Liu & David R. Ambrozak & Amy Ransier & Farida Laboune & Jianfei Hu & Wei Shi & Kylie March & Anna A. Maximova & Stephen D. Schmidt &, 2024. "Administration of anti-HIV-1 broadly neutralizing monoclonal antibodies with increased affinity to Fcγ receptors during acute SHIVAD8-EO infection," Nature Communications, Nature, vol. 15(1), pages 1-18, December.

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