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Viraemia suppressed in HIV-1-infected humans by broadly neutralizing antibody 3BNC117

Author

Listed:
  • Marina Caskey

    (Laboratory of Molecular Immunology, The Rockefeller University)

  • Florian Klein

    (Laboratory of Molecular Immunology, The Rockefeller University)

  • Julio C. C. Lorenzi

    (Laboratory of Molecular Immunology, The Rockefeller University)

  • Michael S. Seaman

    (Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School)

  • Anthony P. West

    (California Institute of Technology)

  • Noreen Buckley

    (Laboratory of Molecular Immunology, The Rockefeller University)

  • Gisela Kremer

    (University Hospital of Cologne
    Clinical Trials Center Cologne, ZKS Köln, BMBF 01KN1106, University of Cologne)

  • Lilian Nogueira

    (Laboratory of Molecular Immunology, The Rockefeller University)

  • Malte Braunschweig

    (Laboratory of Molecular Immunology, The Rockefeller University
    Albert Ludwigs University of Freiburg)

  • Johannes F. Scheid

    (Laboratory of Molecular Immunology, The Rockefeller University)

  • Joshua A. Horwitz

    (Laboratory of Molecular Immunology, The Rockefeller University)

  • Irina Shimeliovich

    (Laboratory of Molecular Immunology, The Rockefeller University)

  • Sivan Ben-Avraham

    (Laboratory of Molecular Immunology, The Rockefeller University)

  • Maggi Witmer-Pack

    (Laboratory of Molecular Immunology, The Rockefeller University)

  • Martin Platten

    (University Hospital of Cologne
    German Center for Infection Research (DZIF))

  • Clara Lehmann

    (University Hospital of Cologne
    German Center for Infection Research (DZIF))

  • Leah A. Burke

    (Laboratory of Molecular Immunology, The Rockefeller University
    Weill Medical College of Cornell University)

  • Thomas Hawthorne

    (Celldex Therapeutics, Inc.)

  • Robert J. Gorelick

    (AIDS and Cancer Virus Program, Leidos Biomedical Research, Frederick, Frederick National Laboratory for Cancer Research)

  • Bruce D. Walker

    (Ragon Institute of MGH, MIT and Harvard, Howard Hughes Medical Institute, Massachusetts General Hospital and Harvard Medical School)

  • Tibor Keler

    (Celldex Therapeutics, Inc.)

  • Roy M. Gulick

    (Weill Medical College of Cornell University)

  • Gerd Fätkenheuer

    (University Hospital of Cologne
    German Center for Infection Research (DZIF))

  • Sarah J. Schlesinger

    (Laboratory of Molecular Immunology, The Rockefeller University)

  • Michel C. Nussenzweig

    (Laboratory of Molecular Immunology, The Rockefeller University
    Howard Hughes Medical Institute, The Rockefeller University)

Abstract

A phase I study of passive immunization with a CD4 binding-site-directed broadly neutralizing antibody shows that it transiently reduces HIV-1 viral loads in humans.

Suggested Citation

  • Marina Caskey & Florian Klein & Julio C. C. Lorenzi & Michael S. Seaman & Anthony P. West & Noreen Buckley & Gisela Kremer & Lilian Nogueira & Malte Braunschweig & Johannes F. Scheid & Joshua A. Horwi, 2015. "Viraemia suppressed in HIV-1-infected humans by broadly neutralizing antibody 3BNC117," Nature, Nature, vol. 522(7557), pages 487-491, June.
    • Handle: RePEc:nat:nature:v:522:y:2015:i:7557:d:10.1038_nature14411
    DOI: 10.1038/nature14411
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    Citations

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    Cited by:

    1. Joana Dias & Giulia Fabozzi & Slim Fourati & Xuejun Chen & Cuiping Liu & David R. Ambrozak & Amy Ransier & Farida Laboune & Jianfei Hu & Wei Shi & Kylie March & Anna A. Maximova & Stephen D. Schmidt &, 2024. "Administration of anti-HIV-1 broadly neutralizing monoclonal antibodies with increased affinity to Fcγ receptors during acute SHIVAD8-EO infection," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    2. Christoph Kreer & Cosimo Lupo & Meryem S. Ercanoglu & Lutz Gieselmann & Natanael Spisak & Jan Grossbach & Maike Schlotz & Philipp Schommers & Henning Gruell & Leona Dold & Andreas Beyer & Armita Nourm, 2023. "Probabilities of developing HIV-1 bNAb sequence features in uninfected and chronically infected individuals," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    3. Miriam Rosás-Umbert & Jesper D. Gunst & Marie H. Pahus & Rikke Olesen & Mariane Schleimann & Paul W. Denton & Victor Ramos & Adam Ward & Natalie N. Kinloch & Dennis C. Copertino & Tuixent Escribà & An, 2022. "Administration of broadly neutralizing anti-HIV-1 antibodies at ART initiation maintains long-term CD8+ T cell immunity," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    4. Karunasinee Suphaphiphat & Delphine Desjardins & Valérie Lorin & Nastasia Dimant & Kawthar Bouchemal & Laetitia Bossevot & Maxence Galpin-Lebreau & Nathalie Dereuddre-Bosquet & Hugo Mouquet & Roger Gr, 2023. "Mucosal application of the broadly neutralizing antibody 10-1074 protects macaques from cell-associated SHIV vaginal exposure," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    5. Anna Hake & Nico Pfeifer, 2017. "Prediction of HIV-1 sensitivity to broadly neutralizing antibodies shows a trend towards resistance over time," PLOS Computational Biology, Public Library of Science, vol. 13(10), pages 1-23, October.

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