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Fc receptor but not complement binding is important in antibody protection against HIV

Author

Listed:
  • Ann J. Hessell

    (The Scripps Research Institute, La Jolla, California 92037, USA)

  • Lars Hangartner

    (The Scripps Research Institute, La Jolla, California 92037, USA)

  • Meredith Hunter

    (Tulane National Primate Research Center, Tulane University, Covington, Louisiana 70433, USA)

  • Carin E. G. Havenith

    (Genmab)

  • Frank J. Beurskens

    (Genmab)

  • Joost M. Bakker

    (Genmab)

  • Caroline M. S. Lanigan

    (The Scripps Research Institute, La Jolla, California 92037, USA)

  • Gary Landucci

    (University of California, Irvine School of Medicine, Irvine, California 92697, USA)

  • Donald N. Forthal

    (University of California, Irvine School of Medicine, Irvine, California 92697, USA)

  • Paul W. H. I. Parren

    (Genmab)

  • Preston A. Marx

    (Tulane National Primate Research Center, Tulane University, Covington, Louisiana 70433, USA)

  • Dennis R. Burton

    (The Scripps Research Institute, La Jolla, California 92037, USA)

Abstract

Double-barrelled vaccines Many effective vaccines act by inducing neutralizing antibodies, and this approach is a top priority in work on HIV vaccines. But a new study suggests that anti-HIV antibodies are most effective when they act in two ways: through neutralization — killing the virus outright and blocking its entry into T cells — and by killing infected cells. The use of engineered versions of a neutralizing human antibody that protects against HIV in a monkey model shows that protection is dependent not only the antibody's neutralizing activity, but also on its interaction with Fc receptors on effector cells, which may act to reduce virus yield from infected cells. This work suggests that the best results might be achieved with vaccines that recruit both neutralizing antibodies and cell-mediated immunity via agents such as macrophages and cytokinins, rather than antibodies.

Suggested Citation

  • Ann J. Hessell & Lars Hangartner & Meredith Hunter & Carin E. G. Havenith & Frank J. Beurskens & Joost M. Bakker & Caroline M. S. Lanigan & Gary Landucci & Donald N. Forthal & Paul W. H. I. Parren & P, 2007. "Fc receptor but not complement binding is important in antibody protection against HIV," Nature, Nature, vol. 449(7158), pages 101-104, September.
  • Handle: RePEc:nat:nature:v:449:y:2007:i:7158:d:10.1038_nature06106
    DOI: 10.1038/nature06106
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    Cited by:

    1. Joana Dias & Giulia Fabozzi & Slim Fourati & Xuejun Chen & Cuiping Liu & David R. Ambrozak & Amy Ransier & Farida Laboune & Jianfei Hu & Wei Shi & Kylie March & Anna A. Maximova & Stephen D. Schmidt &, 2024. "Administration of anti-HIV-1 broadly neutralizing monoclonal antibodies with increased affinity to Fcγ receptors during acute SHIVAD8-EO infection," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    2. Olivier Lambotte & Justin Pollara & Faroudy Boufassa & Christiane Moog & Alain Venet & Barton F Haynes & Jean-François Delfraissy & Asier Saez-Cirion & Guido Ferrari, 2013. "High Antibody-Dependent Cellular Cytotoxicity Responses Are Correlated with Strong CD8 T Cell Viral Suppressive Activity but Not with B57 Status in HIV-1 Elite Controllers," PLOS ONE, Public Library of Science, vol. 8(9), pages 1-5, September.
    3. Lucia Reh & Carsten Magnus & Merle Schanz & Jacqueline Weber & Therese Uhr & Peter Rusert & Alexandra Trkola, 2015. "Capacity of Broadly Neutralizing Antibodies to Inhibit HIV-1 Cell-Cell Transmission Is Strain- and Epitope-Dependent," PLOS Pathogens, Public Library of Science, vol. 11(7), pages 1-34, July.
    4. Karunasinee Suphaphiphat & Delphine Desjardins & Valérie Lorin & Nastasia Dimant & Kawthar Bouchemal & Laetitia Bossevot & Maxence Galpin-Lebreau & Nathalie Dereuddre-Bosquet & Hugo Mouquet & Roger Gr, 2023. "Mucosal application of the broadly neutralizing antibody 10-1074 protects macaques from cell-associated SHIV vaginal exposure," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    5. David A. Spencer & Benjamin S. Goldberg & Shilpi Pandey & Tracy Ordonez & Jérémy Dufloo & Philip Barnette & William F. Sutton & Heidi Henderson & Rebecca Agnor & Lina Gao & Timothée Bruel & Olivier Sc, 2022. "Phagocytosis by an HIV antibody is associated with reduced viremia irrespective of enhanced complement lysis," Nature Communications, Nature, vol. 13(1), pages 1-14, December.

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