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CoPoP liposomes displaying stabilized clade C HIV-1 Env elicit tier 2 multiclade neutralization in rabbits

Author

Listed:
  • Annemart Koornneef

    (Janssen Vaccines & Prevention)

  • Kanika Vanshylla

    (Janssen Vaccines & Prevention)

  • Gijs Hardenberg

    (Janssen Vaccines & Prevention)

  • Lucy Rutten

    (Janssen Vaccines & Prevention)

  • Nika M. Strokappe

    (Janssen Vaccines & Prevention)

  • Jeroen Tolboom

    (Janssen Vaccines & Prevention)

  • Jessica Vreugdenhil

    (Janssen Vaccines & Prevention)

  • Karin Feddes-de Boer

    (Janssen Vaccines & Prevention)

  • Aditya Perkasa

    (Janssen Vaccines & Prevention)

  • Sven Blokland

    (Janssen Vaccines & Prevention)

  • Judith A. Burger

    (University of Amsterdam, Amsterdam Institute for Infection and Immunity)

  • Wei-Chiao Huang

    (University at Buffalo)

  • Jonathan F. Lovell

    (University at Buffalo)

  • Danielle Manen

    (Janssen Vaccines & Prevention)

  • Rogier W. Sanders

    (University of Amsterdam, Amsterdam Institute for Infection and Immunity)

  • Roland C. Zahn

    (Janssen Vaccines & Prevention)

  • Hanneke Schuitemaker

    (Janssen Vaccines & Prevention)

  • Johannes P. M. Langedijk

    (Janssen Vaccines & Prevention
    ForgeBio)

  • Frank Wegmann

    (Janssen Vaccines & Prevention)

Abstract

One of the strategies towards an effective HIV-1 vaccine is to elicit broadly neutralizing antibody responses that target the high HIV-1 Env diversity. Here, we present an HIV-1 vaccine candidate that consists of cobalt porphyrin-phospholipid (CoPoP) liposomes decorated with repaired and stabilized clade C HIV-1 Env trimers in a prefusion conformation. These particles exhibit high HIV-1 Env trimer decoration, serum stability and bind broadly neutralizing antibodies. Three sequential immunizations of female rabbits with CoPoP liposomes displaying a different clade C HIV-1 gp140 trimer at each dosing generate high HIV-1 Env-specific antibody responses. Additionally, serum neutralization is detectable against 18 of 20 multiclade tier 2 HIV-1 strains. Furthermore, the peak antibody titers induced by CoPoP liposomes can be recalled by subsequent heterologous immunization with Ad26-encoded membrane-bound stabilized Env antigens. Hence, a CoPoP liposome-based HIV-1 vaccine that can generate cross-clade neutralizing antibody immunity could potentially be a component of an efficacious HIV-1 vaccine.

Suggested Citation

  • Annemart Koornneef & Kanika Vanshylla & Gijs Hardenberg & Lucy Rutten & Nika M. Strokappe & Jeroen Tolboom & Jessica Vreugdenhil & Karin Feddes-de Boer & Aditya Perkasa & Sven Blokland & Judith A. Bur, 2024. "CoPoP liposomes displaying stabilized clade C HIV-1 Env elicit tier 2 multiclade neutralization in rabbits," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-47492-1
    DOI: 10.1038/s41467-024-47492-1
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