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Inter-continental variability in the relationship of oxidative potential and cytotoxicity with PM2.5 mass

Author

Listed:
  • Sudheer Salana

    (University of Illinois at Urbana Champaign)

  • Haoran Yu

    (University of Illinois at Urbana Champaign
    University of Alberta)

  • Zhuying Dai

    (University of Illinois at Urbana Champaign)

  • P. S. Ganesh Subramanian

    (University of Illinois at Urbana Champaign)

  • Joseph V. Puthussery

    (University of Illinois at Urbana Champaign
    Washington University in St. Louis)

  • Yixiang Wang

    (University of Illinois at Urbana Champaign
    Lehigh University)

  • Ajit Singh

    (University of Birmingham
    University of Birmingham, Edgbaston)

  • Francis D. Pope

    (University of Birmingham)

  • Manuel A. Leiva G.

    (Universidad de Chile, Las Palmeras 3425, Ñuñoa)

  • Neeraj Rastogi

    (Physical Research Laboratory)

  • Sachchida Nand Tripathi

    (Indian Institute of Technology Kanpur
    Indian Institute of Technology Kanpur)

  • Rodney J. Weber

    (Georgia Institute of Technology)

  • Vishal Verma

    (University of Illinois at Urbana Champaign)

Abstract

Most fine ambient particulate matter (PM2.5)-based epidemiological models use globalized concentration-response (CR) functions assuming that the toxicity of PM2.5 is solely mass-dependent without considering its chemical composition. Although oxidative potential (OP) has emerged as an alternate metric of PM2.5 toxicity, the association between PM2.5 mass and OP on a large spatial extent has not been investigated. In this study, we evaluate this relationship using 385 PM2.5 samples collected from 14 different sites across 4 different continents and using 5 different OP (and cytotoxicity) endpoints. Our results show that the relationship between PM2.5 mass vs. OP (and cytotoxicity) is largely non-linear due to significant differences in the intrinsic toxicity, resulting from a spatially heterogeneous chemical composition of PM2.5. These results emphasize the need to develop localized CR functions incorporating other measures of PM2.5 properties (e.g., OP) to better predict the PM2.5-attributed health burdens.

Suggested Citation

  • Sudheer Salana & Haoran Yu & Zhuying Dai & P. S. Ganesh Subramanian & Joseph V. Puthussery & Yixiang Wang & Ajit Singh & Francis D. Pope & Manuel A. Leiva G. & Neeraj Rastogi & Sachchida Nand Tripathi, 2024. "Inter-continental variability in the relationship of oxidative potential and cytotoxicity with PM2.5 mass," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-49649-4
    DOI: 10.1038/s41467-024-49649-4
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    References listed on IDEAS

    as
    1. Chandima N. P. G. Arachchige & Luke A. Prendergast & Robert G. Staudte, 2022. "Robust analogs to the coefficient of variation," Journal of Applied Statistics, Taylor & Francis Journals, vol. 49(2), pages 268-290, January.
    2. Kaspar R. Daellenbach & Gaëlle Uzu & Jianhui Jiang & Laure-Estelle Cassagnes & Zaira Leni & Athanasia Vlachou & Giulia Stefenelli & Francesco Canonaco & Samuël Weber & Arjo Segers & Jeroen J. P. Kuene, 2020. "Sources of particulate-matter air pollution and its oxidative potential in Europe," Nature, Nature, vol. 587(7834), pages 414-419, November.
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