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Rapid room-temperature phosphorescence chiral recognition of natural amino acids

Author

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  • Xiaoyu Chen

    (University of Science and Technology of China)

  • Renlong Zhu

    (University of Science and Technology of China)

  • Baicheng Zhang

    (University of Science and Technology of China)

  • Xiaolong Zhang

    (University of Science and Technology of China)

  • Aoyuan Cheng

    (University of Science and Technology of China)

  • Hongping Liu

    (University of Science and Technology of China)

  • Ruiying Gao

    (University of Science and Technology of China)

  • Xuepeng Zhang

    (University of Science and Technology of China)

  • Biao Chen

    (University of Science and Technology of China)

  • Shuji Ye

    (University of Science and Technology of China)

  • Jun Jiang

    (University of Science and Technology of China)

  • Guoqing Zhang

    (University of Science and Technology of China
    University of Science and Technology of China)

Abstract

Chiral recognition of amino acids is very important in both chemical and life sciences. Although chiral recognition with luminescence has many advantages such as being inexpensive, it is usually slow and lacks generality as the recognition module relies on structural complementarity. Here, we show that one single molecular-solid sensor, L-phenylalanine derived benzamide, can manifest the structural difference between the natural, left-handed amino acid and its right-handed counterpart via the difference of room-temperature phosphorescence (RTP) irrespective of the specific chemical structure. To realize rapid and reliable sensing, the doped samples are obtained as nanocrystals from evaporation of the tetrahydrofuran solutions, which allows for efficient triplet-triplet energy transfer to the chiral analytes generated in situ from chiral amino acids. The results show that L-analytes induce strong RTP, whereas the unnatural D-analytes produce barely any afterglow. The method expands the scope of luminescence chiral sensing by lessening the requirement for specific molecular structures.

Suggested Citation

  • Xiaoyu Chen & Renlong Zhu & Baicheng Zhang & Xiaolong Zhang & Aoyuan Cheng & Hongping Liu & Ruiying Gao & Xuepeng Zhang & Biao Chen & Shuji Ye & Jun Jiang & Guoqing Zhang, 2024. "Rapid room-temperature phosphorescence chiral recognition of natural amino acids," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-47648-z
    DOI: 10.1038/s41467-024-47648-z
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    References listed on IDEAS

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    1. Xin Zhang & Yaohui Cheng & Jingxuan You & Jinming Zhang & Chunchun Yin & Jun Zhang, 2022. "Ultralong phosphorescence cellulose with excellent anti-bacterial, water-resistant and ease-to-process performance," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    2. Xuepeng Zhang & Lili Du & Weijun Zhao & Zheng Zhao & Yu Xiong & Xuewen He & Peng Fei Gao & Parvej Alam & Can Wang & Zhen Li & Jing Leng & Junxue Liu & Chuanyao Zhou & Jacky W. Y. Lam & David Lee Phill, 2019. "Ultralong UV/mechano-excited room temperature phosphorescence from purely organic cluster excitons," Nature Communications, Nature, vol. 10(1), pages 1-10, December.
    3. Biao Chen & Wenhuan Huang & Guoqing Zhang, 2023. "Observation of Chiral-selective room-temperature phosphorescence enhancement via chirality-dependent energy transfer," Nature Communications, Nature, vol. 14(1), pages 1-8, December.
    4. Ryota Kabe & Chihaya Adachi, 2017. "Organic long persistent luminescence," Nature, Nature, vol. 550(7676), pages 384-387, October.
    5. Hui Li & Jie Gu & Zijie Wang & Juan Wang & Fei He & Ping Li & Ye Tao & Huanhuan Li & Gaozhan Xie & Wei Huang & Chao Zheng & Runfeng Chen, 2022. "Single-component color-tunable circularly polarized organic afterglow through chiral clusterization," Nature Communications, Nature, vol. 13(1), pages 1-8, December.
    6. Qiuhong Cheng & Aiyou Hao & Pengyao Xing, 2021. "A chemosensor-based chiral coassembly with switchable circularly polarized luminescence," Nature Communications, Nature, vol. 12(1), pages 1-11, December.
    7. Wei-Lei Zhou & Yong Chen & Qilin Yu & Haoyang Zhang & Zhi-Xue Liu & Xian-Yin Dai & Jing-Jing Li & Yu Liu, 2020. "Ultralong purely organic aqueous phosphorescence supramolecular polymer for targeted tumor cell imaging," Nature Communications, Nature, vol. 11(1), pages 1-10, December.
    8. Dan Li & Yujie Yang & Jie Yang & Manman Fang & Ben Zhong Tang & Zhen Li, 2022. "Completely aqueous processable stimulus responsive organic room temperature phosphorescence materials with tunable afterglow color," Nature Communications, Nature, vol. 13(1), pages 1-8, December.
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