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Functional plasticity of glutamatergic neurons of medullary reticular nuclei after spinal cord injury in mice

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  • Maxime Lemieux

    (Centre de Recherche du CHU de Québec, CHUL-Neurosciences)

  • Narges Karimi

    (Centre de Recherche du CHU de Québec, CHUL-Neurosciences
    Université Laval)

  • Frederic Bretzner

    (Centre de Recherche du CHU de Québec, CHUL-Neurosciences
    Université Laval)

Abstract

Spinal cord injury disrupts the descending command from the brain and causes a range of motor deficits. Here, we use optogenetic tools to investigate the functional plasticity of the glutamatergic reticulospinal drive of the medullary reticular formation after a lateral thoracic hemisection in female mice. Sites evoking stronger excitatory descending drive in intact conditions are the most impaired after injury, whereas those associated with a weaker drive are potentiated. After lesion, pro- and anti-locomotor activities (that is, initiation/acceleration versus stop/deceleration) are overall preserved. Activating the descending reticulospinal drive improves stepping ability on a flat surface of chronically impaired injured mice, and its priming enhances recovery of skilled locomotion on a horizontal ladder. This study highlights the resilience and capacity for reorganization of the glutamatergic reticulospinal command after injury, along with its suitability as a therapeutical target to promote functional recovery.

Suggested Citation

  • Maxime Lemieux & Narges Karimi & Frederic Bretzner, 2024. "Functional plasticity of glutamatergic neurons of medullary reticular nuclei after spinal cord injury in mice," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-45300-4
    DOI: 10.1038/s41467-024-45300-4
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