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Histamine-tuned subicular circuit mediates alert-driven accelerated locomotion in mice

Author

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  • Lin Yang

    (Zhejiang Chinese Medical University)

  • Mengdi Zhang

    (Zhejiang Chinese Medical University)

  • Yuan Zhou

    (Zhejiang Chinese Medical University)

  • Dongxiao Jiang

    (Zhejiang Chinese Medical University)

  • Lilong Yu

    (Zhejiang Chinese Medical University)

  • Lingyu Xu

    (Zhejiang Chinese Medical University)

  • Fan Fei

    (Zhejiang Chinese Medical University)

  • Wenkai Lin

    (Zhejiang Chinese Medical University)

  • Yanrong Zheng

    (Zhejiang Chinese Medical University)

  • Jiannong Wu

    (Zhejiang Chinese Medical University)

  • Yi Wang

    (Zhejiang Chinese Medical University
    The Third Affiliated Hospital of Zhejiang Chinese Medical University
    Zhejiang University)

  • Zhong Chen

    (Zhejiang Chinese Medical University
    Zhejiang University)

Abstract

The locomotive action involves diverse coordination, necessitating the integration of multiple motor neural circuits. However, the precise circuitry mechanism governing emotion-driven accelerated locomotion remains predominantly elusive. Here we dissect projections from the tuberomammillary nucleus (TMN) to subiculum (SUB) which promote alert-driven accelerated locomotion. We find that TMN histaminergic neurons respond to high-speed locomotion in both natural and alert acceleration. The TMN-SUB circuit is sufficient but not essential for amplifying accelerated locomotion from low to high-speed movement in basal condition, but it is both sufficient and necessary in alert condition for modulating accelerated locomotion during high-speed escape behavior. TMN histaminergic neuron activates SUB glutamatergic “fast locomotor cell” that projects to retrosplenial granular cortex (RSG) mainly through histamine H2 receptor (H2R). This study reveals the critical role of the histamine-tuned SUB circuit in alert-driven accelerated locomotion in mice, providing a theoretical foundation for comprehending neural circuit mechanisms of instinctive behaviors under alert.

Suggested Citation

  • Lin Yang & Mengdi Zhang & Yuan Zhou & Dongxiao Jiang & Lilong Yu & Lingyu Xu & Fan Fei & Wenkai Lin & Yanrong Zheng & Jiannong Wu & Yi Wang & Zhong Chen, 2024. "Histamine-tuned subicular circuit mediates alert-driven accelerated locomotion in mice," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-54347-2
    DOI: 10.1038/s41467-024-54347-2
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    References listed on IDEAS

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    1. Emilio Kropff & James E. Carmichael & May-Britt Moser & Edvard I. Moser, 2015. "Speed cells in the medial entorhinal cortex," Nature, Nature, vol. 523(7561), pages 419-424, July.
    2. Paolo Capelli & Chiara Pivetta & Maria Soledad Esposito & Silvia Arber, 2017. "Locomotor speed control circuits in the caudal brainstem," Nature, Nature, vol. 551(7680), pages 373-377, November.
    3. V. Caggiano & R. Leiras & H. Goñi-Erro & D. Masini & C. Bellardita & J. Bouvier & V. Caldeira & G. Fisone & O. Kiehn, 2018. "Midbrain circuits that set locomotor speed and gait selection," Nature, Nature, vol. 553(7689), pages 455-460, January.
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