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Suppressing mosquito populations with precision guided sterile males

Author

Listed:
  • Ming Li

    (University of California, San Diego)

  • Ting Yang

    (University of California, San Diego)

  • Michelle Bui

    (University of California, San Diego)

  • Stephanie Gamez

    (University of California, San Diego)

  • Tyler Wise

    (University of California, San Diego)

  • Nikolay P. Kandul

    (University of California, San Diego)

  • Junru Liu

    (University of California, San Diego)

  • Lenissa Alcantara

    (University of California, San Diego)

  • Haena Lee

    (University of California, San Diego)

  • Jyotheeswara R. Edula

    (University of California, San Diego
    Tata Institute for Genetics and Society
    TIGS Center at inStem, GKVK Campus)

  • Robyn Raban

    (University of California, San Diego)

  • Yinpeng Zhan

    (University of California)

  • Yijin Wang

    (University of California)

  • Nick DeBeaubien

    (University of California)

  • Jieyan Chen

    (University of California)

  • Héctor M. Sánchez C.

    (University of California)

  • Jared B. Bennett

    (University of California
    University of California)

  • Igor Antoshechkin

    (California Institute of Technology)

  • Craig Montell

    (University of California)

  • John M. Marshall

    (University of California
    Innovative Genomics Institute, University of California)

  • Omar S. Akbari

    (University of California, San Diego
    Tata Institute for Genetics and Society)

Abstract

The mosquito Aedes aegypti is the principal vector for arboviruses including dengue/yellow fever, chikungunya, and Zika virus, infecting hundreds of millions of people annually. Unfortunately, traditional control methodologies are insufficient, so innovative control methods are needed. To complement existing measures, here we develop a molecular genetic control system termed precision-guided sterile insect technique (pgSIT) in Aedes aegypti. PgSIT uses a simple CRISPR-based approach to generate flightless females and sterile males that are deployable at any life stage. Supported by mathematical models, we empirically demonstrate that released pgSIT males can compete, suppress, and even eliminate mosquito populations. This platform technology could be used in the field, and adapted to many vectors, for controlling wild populations to curtail disease in a safe, confinable, and reversible manner.

Suggested Citation

  • Ming Li & Ting Yang & Michelle Bui & Stephanie Gamez & Tyler Wise & Nikolay P. Kandul & Junru Liu & Lenissa Alcantara & Haena Lee & Jyotheeswara R. Edula & Robyn Raban & Yinpeng Zhan & Yijin Wang & Ni, 2021. "Suppressing mosquito populations with precision guided sterile males," Nature Communications, Nature, vol. 12(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-25421-w
    DOI: 10.1038/s41467-021-25421-w
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    Cited by:

    1. Sara Sanz Juste & Emily M. Okamoto & Christina Nguyen & Xuechun Feng & Víctor López Del Amo, 2023. "Next-generation CRISPR gene-drive systems using Cas12a nuclease," Nature Communications, Nature, vol. 14(1), pages 1-8, December.
    2. Xiaomei Sun & Xueli Wang & Kai Shi & Xiangyang Lyu & Jian Sun & Alexander S. Raikhel & Zhen Zou, 2024. "Leucine aminopeptidase1 controls egg deposition and hatchability in male Aedes aegypti mosquitoes," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    3. Weizhe Chen & Jialiang Guo & Yiran Liu & Jackson Champer, 2024. "Population suppression by release of insects carrying a dominant sterile homing gene drive targeting doublesex in Drosophila," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    4. Stephanie Gamez & Duverney Chaverra-Rodriguez & Anna Buchman & Nikolay P. Kandul & Stelia C. Mendez-Sanchez & Jared B. Bennett & Héctor M. Sánchez C. & Ting Yang & Igor Antoshechkin & Jonny E. Duque &, 2021. "Exploiting a Y chromosome-linked Cas9 for sex selection and gene drive," Nature Communications, Nature, vol. 12(1), pages 1-14, December.

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