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Mapping protein states and interactions across the tree of life with co-fractionation mass spectrometry

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  • Michael A. Skinnider

    (University of British Columbia
    Princeton University
    Princeton University)

  • Mopelola O. Akinlaja

    (University of British Columbia
    University of British Columbia)

  • Leonard J. Foster

    (University of British Columbia
    University of British Columbia)

Abstract

We present CFdb, a harmonized resource of interaction proteomics data from 411 co-fractionation mass spectrometry (CF-MS) datasets spanning 21,703 fractions. Meta-analysis of this resource charts protein abundance, phosphorylation, and interactions throughout the tree of life, including a reference map of the human interactome. We show how large-scale CF-MS data can enhance analyses of individual CF-MS datasets, and exemplify this strategy by mapping the honey bee interactome.

Suggested Citation

  • Michael A. Skinnider & Mopelola O. Akinlaja & Leonard J. Foster, 2023. "Mapping protein states and interactions across the tree of life with co-fractionation mass spectrometry," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-44139-5
    DOI: 10.1038/s41467-023-44139-5
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    References listed on IDEAS

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    1. Ella Doron-Mandel & Benjamin J. Bokor & Yanzhe Ma & Lena A. Street & Lauren C. Tang & Ahmed A. Abdou & Neel H. Shah & George Rosenberger & Marko Jovanovic, 2025. "SEC-MX: an approach to systematically study the interplay between protein assembly states and phosphorylation," Nature Communications, Nature, vol. 16(1), pages 1-20, December.

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