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Architecture of the human interactome defines protein communities and disease networks

Author

Listed:
  • Edward L. Huttlin

    (Harvard Medical School)

  • Raphael J. Bruckner

    (Harvard Medical School)

  • Joao A. Paulo

    (Harvard Medical School)

  • Joe R. Cannon

    (Harvard Medical School)

  • Lily Ting

    (Harvard Medical School)

  • Kurt Baltier

    (Harvard Medical School)

  • Greg Colby

    (Harvard Medical School)

  • Fana Gebreab

    (Harvard Medical School)

  • Melanie P. Gygi

    (Harvard Medical School)

  • Hannah Parzen

    (Harvard Medical School)

  • John Szpyt

    (Harvard Medical School)

  • Stanley Tam

    (Harvard Medical School)

  • Gabriela Zarraga

    (Harvard Medical School)

  • Laura Pontano-Vaites

    (Harvard Medical School)

  • Sharan Swarup

    (Harvard Medical School)

  • Anne E. White

    (Harvard Medical School)

  • Devin K. Schweppe

    (Harvard Medical School)

  • Ramin Rad

    (Harvard Medical School)

  • Brian K. Erickson

    (Harvard Medical School)

  • Robert A. Obar

    (Harvard Medical School
    Biogen Inc.)

  • K. G. Guruharsha

    (Biogen Inc.)

  • Kejie Li

    (Biogen Inc.)

  • Spyros Artavanis-Tsakonas

    (Harvard Medical School
    Biogen Inc.)

  • Steven P. Gygi

    (Harvard Medical School)

  • J. Wade Harper

    (Harvard Medical School)

Abstract

Affinity purification–mass spectrometry elucidates protein interaction networks and co-complexes to build, to our knowledge, the largest experimentally derived human protein interaction network so far, termed BioPlex 2.0.

Suggested Citation

  • Edward L. Huttlin & Raphael J. Bruckner & Joao A. Paulo & Joe R. Cannon & Lily Ting & Kurt Baltier & Greg Colby & Fana Gebreab & Melanie P. Gygi & Hannah Parzen & John Szpyt & Stanley Tam & Gabriela Z, 2017. "Architecture of the human interactome defines protein communities and disease networks," Nature, Nature, vol. 545(7655), pages 505-509, May.
    • Handle: RePEc:nat:nature:v:545:y:2017:i:7655:d:10.1038_nature22366
    DOI: 10.1038/nature22366
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    Cited by:

    1. Akshat Singhal & Song Cao & Christopher Churas & Dexter Pratt & Santo Fortunato & Fan Zheng & Trey Ideker, 2020. "Multiscale community detection in Cytoscape," PLOS Computational Biology, Public Library of Science, vol. 16(10), pages 1-10, October.
    2. Mahmoud H Elbatreek & Sepideh Sadegh & Elisa Anastasi & Emre Guney & Cristian Nogales & Tim Kacprowski & Ahmed A Hassan & Andreas Teubner & Po-Hsun Huang & Chien-Yi Hsu & Paul M H Schiffers & Ger M Ja, 2020. "NOX5-induced uncoupling of endothelial NO synthase is a causal mechanism and theragnostic target of an age-related hypertension endotype," PLOS Biology, Public Library of Science, vol. 18(11), pages 1-25, November.
    3. Sabrina Villar-Pazos & Laurel Thomas & Yunhan Yang & Kun Chen & Jenea B. Lyles & Bradley J. Deitch & Joseph Ochaba & Karen Ling & Berit Powers & Sebastien Gingras & Holly B. Kordasiewicz & Melanie J. , 2023. "Neural deficits in a mouse model of PACS1 syndrome are corrected with PACS1- or HDAC6-targeting therapy," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    4. Qian Jiang & Qijin Zhao & Yibing Chen & Chunxiao Ma & Xiaohong Peng & Xi Wu & Xingfeng Liu & Ruoran Wang & Shaocong Hou & Lijuan Kong & Yanjun Wan & Shusen Wang & Zhuo-Xian Meng & Bing Cui & Liangyi C, 2024. "Galectin-3 impairs calcium transients and β-cell function," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    5. Xing Chen & Chunyu Yu & Xinhua Liu & Beibei Liu & Xiaodi Wu & Jiajing Wu & Dong Yan & Lulu Han & Zifan Tang & Xinyi Yuan & Jianqiu Wang & Yue Wang & Shumeng Liu & Lin Shan & Yongfeng Shang, 2022. "Intracellular galectin-3 is a lipopolysaccharide sensor that promotes glycolysis through mTORC1 activation," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    6. Xinxin Xu & Sheng Ma & Ziqiang Zeng, 2019. "Complex network analysis of bilateral international investment under de-globalization: Structural properties and evolution," PLOS ONE, Public Library of Science, vol. 14(4), pages 1-16, April.
    7. Bai, Ling & Xiong, Long & Zhao, Na & Xia, Ke & Jiang, Xiong-Fei, 2022. "Dynamical structure of social map in ancient China," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 607(C).
    8. Weize Wang & Ling Liang & Zonglin Dai & Peng Zuo & Shang Yu & Yishuo Lu & Dian Ding & Hongyi Chen & Hui Shan & Yan Jin & Youdong Mao & Yuxin Yin, 2024. "A conserved N-terminal motif of CUL3 contributes to assembly and E3 ligase activity of CRL3KLHL22," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    9. Michael A. Skinnider & Mopelola O. Akinlaja & Leonard J. Foster, 2023. "Mapping protein states and interactions across the tree of life with co-fractionation mass spectrometry," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    10. Jiang, Xiongfei & Xiong, Long & Bai, Ling & Zhao, Na & Zhang, Jiu & Xia, Ke & Deng, Kai & Zheng, Bo, 2021. "Quantifying the social structure of elites in ancient China," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 573(C).
    11. Ann Schirin Mirsanaye & Saskia Hoffmann & Melanie Weisser & Andreas Mund & Blanca Lopez Mendez & Dimitris Typas & Johannes Boom & Bente Benedict & Ivo A. Hendriks & Michael Lund Nielsen & Hemmo Meyer , 2024. "VCF1 is a p97/VCP cofactor promoting recognition of ubiquitylated p97-UFD1-NPL4 substrates," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    12. Nilesh Kumar & M. Shahid Mukhtar, 2024. "Viral Targets in the Human Interactome with Comprehensive Centrality Analysis: SARS-CoV-2, a Case Study," Data, MDPI, vol. 9(8), pages 1-12, August.

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