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Multiplexing of temporal and spatial information in the lateral entorhinal cortex

Author

Listed:
  • Cheng Wang

    (Chinese Academy of Sciences
    Chinese Academy of Sciences
    Chinese Academy of Sciences
    Chinese Academy of Sciences)

  • Heekyung Lee

    (Johns Hopkins University)

  • Geeta Rao

    (Johns Hopkins University)

  • James J. Knierim

    (Johns Hopkins University
    Johns Hopkins University
    Johns Hopkins University)

Abstract

Episodic memory involves the processing of spatial and temporal aspects of personal experiences. The lateral entorhinal cortex (LEC) plays an essential role in subserving memory. However, the mechanisms by which LEC integrates spatial and temporal information remain elusive. Here, we recorded LEC neurons while male rats performed one-dimensional tasks. Many LEC cells displayed spatial firing fields and demonstrated selectivity for traveling directions. Furthermore, some LEC neurons changed the firing rates of their spatial rate maps during a session (rate remapping). Importantly, this temporal modulation was consistent across sessions, even when the spatial environment was altered. Notably, the strength of temporal modulation was greater in LEC compared to other brain regions, such as the medial entorhinal cortex, CA1, and CA3. Thus, we demonstrate spatial rate mapping in LEC neurons, which may serve as a coding mechanism for temporal context, and allow for flexible multiplexing of spatial and temporal information.

Suggested Citation

  • Cheng Wang & Heekyung Lee & Geeta Rao & James J. Knierim, 2024. "Multiplexing of temporal and spatial information in the lateral entorhinal cortex," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-54932-5
    DOI: 10.1038/s41467-024-54932-5
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    References listed on IDEAS

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    1. Albert Tsao & Jørgen Sugar & Li Lu & Cheng Wang & James J. Knierim & May-Britt Moser & Edvard I. Moser, 2018. "Integrating time from experience in the lateral entorhinal cortex," Nature, Nature, vol. 561(7721), pages 57-62, September.
    2. Emilio Kropff & James E. Carmichael & May-Britt Moser & Edvard I. Moser, 2015. "Speed cells in the medial entorhinal cortex," Nature, Nature, vol. 523(7561), pages 419-424, July.
    3. Torkel Hafting & Marianne Fyhn & Sturla Molden & May-Britt Moser & Edvard I. Moser, 2005. "Microstructure of a spatial map in the entorhinal cortex," Nature, Nature, vol. 436(7052), pages 801-806, August.
    4. Torkel Hafting & Marianne Fyhn & Tora Bonnevie & May-Britt Moser & Edvard I. Moser, 2008. "Hippocampus-independent phase precession in entorhinal grid cells," Nature, Nature, vol. 453(7199), pages 1248-1252, June.
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