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Bioengineering of bacteria for cancer immunotherapy

Author

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  • Dinh-Huy Nguyen

    (Chonnam National University Medical School and Hospital
    Chonnam National University Graduate School)

  • Ari Chong

    (Chosun University Medical School and Hospital)

  • Yeongjin Hong

    (Chonnam National University Medical School and Hospital
    Chonnam National University Medical School)

  • Jung-Joon Min

    (Chonnam National University Medical School and Hospital
    Chonnam National University Graduate School)

Abstract

Here, we provide a brief overview of the approaches and strategies underlying bacteria-based cancer immunotherapy (BCiT). We also describe and summarize research in the field of synthetic biology, which aims to regulate bacterial growth and gene expression for immunotherapeutic use. Finally, we discuss the current clinical status and limitations of BCiT.

Suggested Citation

  • Dinh-Huy Nguyen & Ari Chong & Yeongjin Hong & Jung-Joon Min, 2023. "Bioengineering of bacteria for cancer immunotherapy," Nature Communications, Nature, vol. 14(1), pages 1-5, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-39224-8
    DOI: 10.1038/s41467-023-39224-8
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    1. Dinh-Huy Nguyen & Sung-Hwan You & Hien Thi-Thu Ngo & Khuynh Nguyen & Khang Vuong Tran & Tan-Huy Chu & So-young Kim & Sang-Jun Ha & Yeongjin Hong & Jung-Joon Min, 2024. "Reprogramming the tumor immune microenvironment using engineered dual-drug loaded Salmonella," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

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