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Synchronized cycles of bacterial lysis for in vivo delivery

Author

Listed:
  • M. Omar Din

    (University of California)

  • Tal Danino

    (Institute for Medical Engineering & Science, Massachusetts Institute of Technology
    † Present address: Department of Biomedical Engineering, Columbia University, New York, New York 10027, USA.These authors contributed equally to this work.)

  • Arthur Prindle

    (University of California)

  • Matt Skalak

    (Institute for Medical Engineering & Science, Massachusetts Institute of Technology)

  • Jangir Selimkhanov

    (University of California)

  • Kaitlin Allen

    (Institute for Medical Engineering & Science, Massachusetts Institute of Technology)

  • Ellixis Julio

    (University of California)

  • Eta Atolia

    (Institute for Medical Engineering & Science, Massachusetts Institute of Technology)

  • Lev S. Tsimring

    (BioCircuits Institute, University of California, San Diego)

  • Sangeeta N. Bhatia

    (Institute for Medical Engineering & Science, Massachusetts Institute of Technology
    Broad Institute of Harvard and MIT
    Brigham and Women’s Hospital
    Electrical Engineering and Computer Science and David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology)

  • Jeff Hasty

    (University of California
    BioCircuits Institute, University of California, San Diego
    Molecular Biology Section, University of California, San Diego)

Abstract

Clinically relevant bacteria have been engineered to lyse synchronously at a threshold population density and release genetically encoded therapeutics; treatment of mice with these bacteria slowed the growth of tumours.

Suggested Citation

  • M. Omar Din & Tal Danino & Arthur Prindle & Matt Skalak & Jangir Selimkhanov & Kaitlin Allen & Ellixis Julio & Eta Atolia & Lev S. Tsimring & Sangeeta N. Bhatia & Jeff Hasty, 2016. "Synchronized cycles of bacterial lysis for in vivo delivery," Nature, Nature, vol. 536(7614), pages 81-85, August.
    • Handle: RePEc:nat:nature:v:536:y:2016:i:7614:d:10.1038_nature18930
    DOI: 10.1038/nature18930
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    Cited by:

    1. Anna-Maria Makri Pistikou & Glenn A. O. Cremers & Bryan L. Nathalia & Theodorus J. Meuleman & Bas W. A. Bögels & Bruno V. Eijkens & Anne Dreu & Maarten T. H. Bezembinder & Oscar M. J. A. Stassen & Car, 2023. "Engineering a scalable and orthogonal platform for synthetic communication in mammalian cells," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    2. Yuhao Chen & Meng Du & Zhen Yuan & Zhiyi Chen & Fei Yan, 2022. "Spatiotemporal control of engineered bacteria to express interferon-γ by focused ultrasound for tumor immunotherapy," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    3. Yunmin Yang & Binbin Chu & Jiayi Cheng & Jiali Tang & Bin Song & Houyu Wang & Yao He, 2022. "Bacteria eat nanoprobes for aggregation-enhanced imaging and killing diverse microorganisms," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    4. Moy, Tiago & Pinto, Italo’Ivo L.D. & Rosas, Alexandre, 2020. "Finite number fluctuations in a three-state model with growing population," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 555(C).
    5. Candice R. Gurbatri & Georgette A. Radford & Laura Vrbanac & Jongwon Im & Elaine M. Thomas & Courtney Coker & Samuel R. Taylor & YoungUk Jang & Ayelet Sivan & Kyu Rhee & Anas A. Saleh & Tiffany Chien , 2024. "Engineering tumor-colonizing E. coli Nissle 1917 for detection and treatment of colorectal neoplasia," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    6. Betz, Ulrich A.K. & Arora, Loukik & Assal, Reem A. & Azevedo, Hatylas & Baldwin, Jeremy & Becker, Michael S. & Bostock, Stefan & Cheng, Vinton & Egle, Tobias & Ferrari, Nicola & Schneider-Futschik, El, 2023. "Game changers in science and technology - now and beyond," Technological Forecasting and Social Change, Elsevier, vol. 193(C).
    7. Xiaotu Ma & Xiaolong Liang & Yao Li & Qingqing Feng & Keman Cheng & Nana Ma & Fei Zhu & Xinjing Guo & Yale Yue & Guangna Liu & Tianjiao Zhang & Jie Liang & Lei Ren & Xiao Zhao & Guangjun Nie, 2023. "Modular-designed engineered bacteria for precision tumor immunotherapy via spatiotemporal manipulation by magnetic field," Nature Communications, Nature, vol. 14(1), pages 1-22, December.
    8. Jung Hun Park & Gábor Holló & Yolanda Schaerli, 2024. "From resonance to chaos by modulating spatiotemporal patterns through a synthetic optogenetic oscillator," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    9. Neythen J Treloar & Alex J H Fedorec & Brian Ingalls & Chris P Barnes, 2020. "Deep reinforcement learning for the control of microbial co-cultures in bioreactors," PLOS Computational Biology, Public Library of Science, vol. 16(4), pages 1-18, April.
    10. Dinh-Huy Nguyen & Ari Chong & Yeongjin Hong & Jung-Joon Min, 2023. "Bioengineering of bacteria for cancer immunotherapy," Nature Communications, Nature, vol. 14(1), pages 1-5, December.
    11. Lucas Henrion & Juan Andres Martinez & Vincent Vandenbroucke & Mathéo Delvenne & Samuel Telek & Andrew Zicler & Alexander Grünberger & Frank Delvigne, 2023. "Fitness cost associated with cell phenotypic switching drives population diversification dynamics and controllability," Nature Communications, Nature, vol. 14(1), pages 1-13, December.

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