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Localized nuclear reaction breaks boron drug capsules loaded with immune adjuvants for cancer immunotherapy

Author

Listed:
  • Yaxin Shi

    (Peking University)

  • Zhibin Guo

    (Peking University)

  • Qiang Fu

    (Nankai University)

  • Xinyuan Shen

    (Zhejiang University)

  • Zhongming Zhang

    (Lancaster University)

  • Wenjia Sun

    (Peking University)

  • Jinqiang Wang

    (Zhejiang University)

  • Junliang Sun

    (Peking University)

  • Zizhu Zhang

    (Beijing Nuclear Industry Hospital)

  • Tong Liu

    (Beijing Capture Tech Co. Ltd)

  • Zhen Gu

    (Zhejiang University
    Jinhua Institute of Zhejiang University
    School of Medicine, Zhejiang University
    Zhejiang University Medical Center)

  • Zhibo Liu

    (Peking University
    Peking University
    Changping Laboratory
    Peking University Cancer Hospital & Institute)

Abstract

Boron neutron capture therapy (BNCT) was clinically approved in 2020 and exhibits remarkable tumour rejection in preclinical and clinical studies. It is binary radiotherapy that may selectively deposit two deadly high-energy particles (4He and 7Li) within a cancer cell. As a radiotherapy induced by localized nuclear reaction, few studies have reported its abscopal anti-tumour effect, which has limited its further clinical applications. Here, we engineer a neutron-activated boron capsule that synergizes BNCT and controlled immune adjuvants release to provoke a potent anti-tumour immune response. This study demonstrates that boron neutron capture nuclear reaction forms considerable defects in boron capsule that augments the drug release. The following single-cell sequencing unveils the fact and mechanism that BNCT heats anti-tumour immunity. In female mice tumour models, BNCT and the controlled drug release triggered by localized nuclear reaction causes nearly complete regression of both primary and distant tumour grafts.

Suggested Citation

  • Yaxin Shi & Zhibin Guo & Qiang Fu & Xinyuan Shen & Zhongming Zhang & Wenjia Sun & Jinqiang Wang & Junliang Sun & Zizhu Zhang & Tong Liu & Zhen Gu & Zhibo Liu, 2023. "Localized nuclear reaction breaks boron drug capsules loaded with immune adjuvants for cancer immunotherapy," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-37253-x
    DOI: 10.1038/s41467-023-37253-x
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    References listed on IDEAS

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