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Water-dispersible PEG-curcumin/amine-functionalized covalent organic framework nanocomposites as smart carriers for in vivo drug delivery

Author

Listed:
  • Guiyang Zhang

    (Nanjing University)

  • Xinle Li

    (Iowa State University)

  • Qiaobo Liao

    (Nanjing University)

  • Yanfeng Liu

    (Nanjing University)

  • Kai Xi

    (Nanjing University)

  • Wenyu Huang

    (Iowa State University)

  • Xudong Jia

    (Nanjing University)

Abstract

Covalent organic frameworks (COFs) as drug-delivery carriers have been mostly evaluated in vitro due to the lack of COFs nanocarriers that are suitable for in vivo studies. Here we develop a series of water-dispersible polymer-COF nanocomposites through the assembly of polyethylene-glycol-modified monofunctional curcumin derivatives (PEG-CCM) and amine-functionalized COFs (APTES-COF-1) for in vitro and in vivo drug delivery. The real-time fluorescence response shows efficient tracking of the COF-based materials upon cellular uptake and anticancer drug (doxorubicin (DOX)) release. Notably, in vitro and in vivo studies demonstrate that PEG-CCM@APTES-COF-1 is a smart carrier for drug delivery with superior stability, intrinsic biodegradability, high DOX loading capacity, strong and stable fluorescence, prolonged circulation time and improved drug accumulation in tumors. More intriguingly, PEG350-CCM@APTES-COF-1 presents an effective targeting strategy for brain research. We envisage that PEG-CCM@APTES-COF-1 nanocomposites represent a great promise toward the development of a multifunctional platform for cancer-targeted in vivo drug delivery.

Suggested Citation

  • Guiyang Zhang & Xinle Li & Qiaobo Liao & Yanfeng Liu & Kai Xi & Wenyu Huang & Xudong Jia, 2018. "Water-dispersible PEG-curcumin/amine-functionalized covalent organic framework nanocomposites as smart carriers for in vivo drug delivery," Nature Communications, Nature, vol. 9(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-04910-5
    DOI: 10.1038/s41467-018-04910-5
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    Cited by:

    1. Yaxin Shi & Zhibin Guo & Qiang Fu & Xinyuan Shen & Zhongming Zhang & Wenjia Sun & Jinqiang Wang & Junliang Sun & Zizhu Zhang & Tong Liu & Zhen Gu & Zhibo Liu, 2023. "Localized nuclear reaction breaks boron drug capsules loaded with immune adjuvants for cancer immunotherapy," Nature Communications, Nature, vol. 14(1), pages 1-15, December.

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