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Astrocytes amplify neurovascular coupling to sustained activation of neocortex in awake mice

Author

Listed:
  • Adam Institoris

    (University of Calgary)

  • Milène Vandal

    (University of Calgary)

  • Govind Peringod

    (University of Calgary)

  • Christy Catalano

    (University of Calgary)

  • Cam Ha Tran

    (University of Calgary
    University of Nevada)

  • Xinzhu Yu

    (University of California Los Angeles
    University of California Los Angeles
    University of Illinois Urbana-Champaign)

  • Frank Visser

    (University of Calgary)

  • Cheryl Breiteneder

    (University of Calgary)

  • Leonardo Molina

    (University of Calgary)

  • Baljit S. Khakh

    (University of California Los Angeles
    University of California Los Angeles)

  • Minh Dang Nguyen

    (University of Calgary)

  • Roger J. Thompson

    (University of Calgary)

  • Grant R. Gordon

    (University of Calgary)

Abstract

Functional hyperemia occurs when enhanced neuronal activity signals to increase local cerebral blood flow (CBF) to satisfy regional energy demand. Ca2+ elevation in astrocytes can drive arteriole dilation to increase CBF, yet affirmative evidence for the necessity of astrocytes in functional hyperemia in vivo is lacking. In awake mice, we discovered that functional hyperemia is bimodal with a distinct early and late component whereby arteriole dilation progresses as sensory stimulation is sustained. Clamping astrocyte Ca2+ signaling in vivo by expressing a plasma membrane Ca2+ ATPase (CalEx) reduces sustained but not brief sensory-evoked arteriole dilation. Elevating astrocyte free Ca2+ using chemogenetics selectively augments sustained hyperemia. Antagonizing NMDA-receptors or epoxyeicosatrienoic acid production reduces only the late component of functional hyperemia, leaving brief increases in CBF to sensory stimulation intact. We propose that a fundamental role of astrocyte Ca2+ is to amplify functional hyperemia when neuronal activation is prolonged.

Suggested Citation

  • Adam Institoris & Milène Vandal & Govind Peringod & Christy Catalano & Cam Ha Tran & Xinzhu Yu & Frank Visser & Cheryl Breiteneder & Leonardo Molina & Baljit S. Khakh & Minh Dang Nguyen & Roger J. Tho, 2022. "Astrocytes amplify neurovascular coupling to sustained activation of neocortex in awake mice," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
  • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-35383-2
    DOI: 10.1038/s41467-022-35383-2
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    Cited by:

    1. Noushin Ahmadpour & Meher Kantroo & Michael J. Stobart & Jessica Meza-Resillas & Shahin Shabanipour & Jesus Parra-Nuñez & Tetiana Salamovska & Anna Muzaleva & Finnegan O’Hara & Dustin Erickson & Bruno, 2024. "Cortical astrocyte N-methyl-D-aspartate receptors influence whisker barrel activity and sensory discrimination in mice," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
    2. Marine Tournissac & Emmanuelle Chaigneau & Sonia Pfister & Ali-Kemal Aydin & Yannick Goulam Houssen & Philip O’Herron & Jessica Filosa & Mayeul Collot & Anne Joutel & Serge Charpak, 2024. "Neurovascular coupling and CO2 interrogate distinct vascular regulations," Nature Communications, Nature, vol. 15(1), pages 1-12, December.

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