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Insular functional organization during handgrip in females and males with obstructive sleep apnea

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  • Amrita Pal
  • Jennifer A Ogren
  • Ravi S Aysola
  • Rajesh Kumar
  • Luke A Henderson
  • Ronald M Harper
  • Paul M Macey

Abstract

Study objectives: Brain regulation of autonomic function in obstructive sleep apnea (OSA) is disrupted in a sex-specific manner, including in the insula, which may contribute to several comorbidities. The insular gyri have anatomically distinct functions with respect to autonomic nervous system regulation; yet, OSA exerts little effect on the organization of insular gyral responses to sympathetic components of an autonomic challenge, the Valsalva. We further assessed neural responses of insular gyri in people with OSA to a static handgrip task, which principally involves parasympathetic withdrawal. Methods: We measured insular function with blood oxygen level dependent functional MRI. We studied 48 newly-diagnosed OSA (age mean±std:46.5±9 years; AHI±std:32.6±21.1 events/hour; 36 male) and 63 healthy (47.2±8.8 years;40 male) participants. Subjects performed four 16s handgrips (1 min intervals, 80% subjective maximum strength) during scanning. fMRI time trends from five insular gyri—anterior short (ASG); mid short (MSG); posterior short (PSG); anterior long (ALG); and posterior long (PLG)—were assessed for within-group responses and between-group differences with repeated measures ANOVA (p

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  • Amrita Pal & Jennifer A Ogren & Ravi S Aysola & Rajesh Kumar & Luke A Henderson & Ronald M Harper & Paul M Macey, 2021. "Insular functional organization during handgrip in females and males with obstructive sleep apnea," PLOS ONE, Public Library of Science, vol. 16(2), pages 1-22, February.
    • Handle: RePEc:plo:pone00:0246368
    DOI: 10.1371/journal.pone.0246368
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