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Long-term potentiation depends on release of d-serine from astrocytes

Author

Listed:
  • Christian Henneberger

    (UCL Institute of Neurology, University College London)

  • Thomas Papouin

    (INSERM U862, Neurocentre Magendie
    Université de Bordeaux)

  • Stéphane H. R. Oliet

    (INSERM U862, Neurocentre Magendie
    Université de Bordeaux)

  • Dmitri A. Rusakov

    (UCL Institute of Neurology, University College London)

Abstract

Role of astrocytes in learning and memory The role of astrocytes in synaptic plasticity has remained controversial. It has been suggested that astrocytes, the star-shaped glial cells found in the brain and spinal cord that were once considered merely passive support cells, are involved in inducing LTP (long-term potentiation) of synaptic transmission — a model for the mechanisms of memory — via the modulation of NMDA-receptor activation and postsynaptic Ca2+ entry. A new study provides more support for that theory by demonstrating that the inhibition of d-serine release from individual astrocytes blocks the potentiation of many nearby neuronal junctions.

Suggested Citation

  • Christian Henneberger & Thomas Papouin & Stéphane H. R. Oliet & Dmitri A. Rusakov, 2010. "Long-term potentiation depends on release of d-serine from astrocytes," Nature, Nature, vol. 463(7278), pages 232-236, January.
    • Handle: RePEc:nat:nature:v:463:y:2010:i:7278:d:10.1038_nature08673
    DOI: 10.1038/nature08673
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    Cited by:

    1. Marta Gómez-Gonzalo & Gabriele Losi & Angela Chiavegato & Micaela Zonta & Mario Cammarota & Marco Brondi & Francesco Vetri & Laura Uva & Tullio Pozzan & Marco de Curtis & Gian Michele Ratto & Giorgio , 2010. "An Excitatory Loop with Astrocytes Contributes to Drive Neurons to Seizure Threshold," PLOS Biology, Public Library of Science, vol. 8(4), pages 1-19, April.
    2. Woo-Hyun Cho & Kyungchul Noh & Byung Hun Lee & Ellane Barcelon & Sang Beom Jun & Hye Yoon Park & Sung Joong Lee, 2022. "Hippocampal astrocytes modulate anxiety-like behavior," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    3. Erkan, Erdem, 2023. "Signal encoding performance of astrocyte-dressed Morris Lecar neurons," Chaos, Solitons & Fractals, Elsevier, vol. 177(C).
    4. Adam Institoris & Milène Vandal & Govind Peringod & Christy Catalano & Cam Ha Tran & Xinzhu Yu & Frank Visser & Cheryl Breiteneder & Leonardo Molina & Baljit S. Khakh & Minh Dang Nguyen & Roger J. Tho, 2022. "Astrocytes amplify neurovascular coupling to sustained activation of neocortex in awake mice," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    5. Rui Dang & An Liu & Yu Zhou & Xingcan Li & Miao Wu & Kun Cao & Yanghong Meng & Haiwang Zhang & Guangming Gan & Wei Xie & Zhengping Jia, 2024. "Astrocytic neuroligin 3 regulates social memory and synaptic plasticity through adenosine signaling in male mice," Nature Communications, Nature, vol. 15(1), pages 1-22, December.
    6. Kirsten Bohmbach & Nicola Masala & Eva M. Schönhense & Katharina Hill & André N. Haubrich & Andreas Zimmer & Thoralf Opitz & Heinz Beck & Christian Henneberger, 2022. "An astrocytic signaling loop for frequency-dependent control of dendritic integration and spatial learning," Nature Communications, Nature, vol. 13(1), pages 1-17, December.

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