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Global and local fMRI signals driven by neurons defined optogenetically by type and wiring

Author

Listed:
  • Jin Hyung Lee

    (Psychiatry and Biobehavioral Sciences, Bioengineering, and Radiology, University of California, Los Angeles, California 90095, USA
    Stanford University, Stanford, California 94305, USA)

  • Remy Durand

    (Stanford University, Stanford, California 94305, USA)

  • Viviana Gradinaru

    (Stanford University, Stanford, California 94305, USA)

  • Feng Zhang

    (Stanford University, Stanford, California 94305, USA)

  • Inbal Goshen

    (Stanford University, Stanford, California 94305, USA)

  • Dae-Shik Kim

    (Korea Advanced Institute of Science and Technology (KAIST)
    Boston University School of Medicine, Boston, Massachusetts 02118, USA)

  • Lief E. Fenno

    (Stanford University, Stanford, California 94305, USA)

  • Charu Ramakrishnan

    (Stanford University, Stanford, California 94305, USA)

  • Karl Deisseroth

    (Stanford University, Stanford, California 94305, USA
    Howard Hughes Medical Institute, Stanford University, Stanford, California 94305, USA
    CNC Program, Stanford University, Stanford, California 94305, USA
    Stanford, California 94305, USA)

Abstract

Why fMRI scanning works Functional magnetic resonance imaging (fMRI) studies are widely used to determine which brain regions are active during particular tasks or behaviours. There is much controversy over the source and interpretation of the BOLD (blood oxygenation level-dependent) signals that this imaging technique detects. Now, using fMRI in combination with optogenetics, a group of excitatory neurons in the rat brain has been identified as a source of the BOLD signals.

Suggested Citation

  • Jin Hyung Lee & Remy Durand & Viviana Gradinaru & Feng Zhang & Inbal Goshen & Dae-Shik Kim & Lief E. Fenno & Charu Ramakrishnan & Karl Deisseroth, 2010. "Global and local fMRI signals driven by neurons defined optogenetically by type and wiring," Nature, Nature, vol. 465(7299), pages 788-792, June.
    • Handle: RePEc:nat:nature:v:465:y:2010:i:7299:d:10.1038_nature09108
    DOI: 10.1038/nature09108
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    Cited by:

    1. Domenic H. Cerri & Daniel L. Albaugh & Lindsay R. Walton & Brittany Katz & Tzu-Wen Wang & Tzu-Hao Harry Chao & Weiting Zhang & Randal J. Nonneman & Jing Jiang & Sung-Ho Lee & Amit Etkin & Catherine N., 2024. "Distinct neurochemical influences on fMRI response polarity in the striatum," Nature Communications, Nature, vol. 15(1), pages 1-23, December.
    2. Adam Institoris & Milène Vandal & Govind Peringod & Christy Catalano & Cam Ha Tran & Xinzhu Yu & Frank Visser & Cheryl Breiteneder & Leonardo Molina & Baljit S. Khakh & Minh Dang Nguyen & Roger J. Tho, 2022. "Astrocytes amplify neurovascular coupling to sustained activation of neocortex in awake mice," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    3. Vinod Menon & Domenic Cerri & Byeongwook Lee & Rui Yuan & Sung-Ho Lee & Yen-Yu Ian Shih, 2023. "Optogenetic stimulation of anterior insular cortex neurons in male rats reveals causal mechanisms underlying suppression of the default mode network by the salience network," Nature Communications, Nature, vol. 14(1), pages 1-14, December.

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