Multi-pathway DNA-repair reporters reveal competition between end-joining, single-strand annealing and homologous recombination at Cas9-induced DNA double-strand breaks
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DOI: 10.1038/s41467-022-32743-w
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- Fatwa Adikusuma & Sandra Piltz & Mark A. Corbett & Michelle Turvey & Shaun R. McColl & Karla J. Helbig & Michael R. Beard & James Hughes & Richard T. Pomerantz & Paul Q. Thomas, 2018. "Large deletions induced by Cas9 cleavage," Nature, Nature, vol. 560(7717), pages 8-9, August.
- Jennifer A. Doudna, 2020. "The promise and challenge of therapeutic genome editing," Nature, Nature, vol. 578(7794), pages 229-236, February.
- Max W. Shen & Mandana Arbab & Jonathan Y. Hsu & Daniel Worstell & Sannie J. Culbertson & Olga Krabbe & Christopher A. Cassa & David R. Liu & David K. Gifford & Richard I. Sherwood, 2018. "Predictable and precise template-free CRISPR editing of pathogenic variants," Nature, Nature, vol. 563(7733), pages 646-651, November.
- Sylvie M. Noordermeer & Salomé Adam & Dheva Setiaputra & Marco Barazas & Stephen J. Pettitt & Alexanda K. Ling & Michele Olivieri & Alejandro Álvarez-Quilón & Nathalie Moatti & Michal Zimmermann & Ste, 2018. "The shieldin complex mediates 53BP1-dependent DNA repair," Nature, Nature, vol. 560(7716), pages 117-121, August.
- Ragini Bhargava & Manbir Sandhu & Sanychen Muk & Gabriella Lee & Nagarajan Vaidehi & Jeremy M. Stark, 2018. "C-NHEJ without indels is robust and requires synergistic function of distinct XLF domains," Nature Communications, Nature, vol. 9(1), pages 1-14, December.
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- Zhusheng Huang & Rong Gu & Shiqian Huang & Qian Chen & Jing Yan & Xiaoya Cui & Haojie Jiang & Dan Yao & Chuang Shen & Jiayue Su & Tao Liu & Jinhui Wu & Zhimin Luo & Yiqiao Hu & Ahu Yuan, 2024. "Chiral coordination polymer nanowires boost radiation-induced in situ tumor vaccination," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
- Shiu Yeung Lam & Ruben Lugt & Aurora Cerutti & Zeliha Yalçin & Alexander M. Thouin & Marco Simonetta & Jacqueline J. L. Jacobs, 2024. "OTUD5 promotes end-joining of deprotected telomeres by promoting ATM-dependent phosphorylation of KAP1S824," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
- Bert Kooij & Fenna J. Wal & Magdalena B. Rother & Wouter W. Wiegant & Pau Creixell & Merula Stout & Brian A. Joughin & Julia Vornberger & Matthias Altmeyer & Marcel A. T. M. Vugt & Michael B. Yaffe & , 2024. "The Fanconi anemia core complex promotes CtIP-dependent end resection to drive homologous recombination at DNA double-strand breaks," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
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