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Chiral coordination polymer nanowires boost radiation-induced in situ tumor vaccination

Author

Listed:
  • Zhusheng Huang

    (Nanjing University
    Nanjing University of Posts and Telecommunications
    University of Macau)

  • Rong Gu

    (Nanjing University)

  • Shiqian Huang

    (Nanjing University of Posts and Telecommunications)

  • Qian Chen

    (Nanjing University)

  • Jing Yan

    (Medical School of Nanjing University)

  • Xiaoya Cui

    (Tsinghua University)

  • Haojie Jiang

    (Nanjing University)

  • Dan Yao

    (Nanjing University)

  • Chuang Shen

    (Nanjing University of Posts and Telecommunications)

  • Jiayue Su

    (Tsinghua University)

  • Tao Liu

    (Tsinghua University)

  • Jinhui Wu

    (Nanjing University)

  • Zhimin Luo

    (Nanjing University of Posts and Telecommunications)

  • Yiqiao Hu

    (Nanjing University)

  • Ahu Yuan

    (Nanjing University)

Abstract

Radiation-induced in situ tumor vaccination alone is very weak and insufficient to elicit robust antitumor immune responses. In this work, we address this issue by developing chiral vidarabine monophosphate-gadolinium nanowires (aAGd-NWs) through coordination-driven self-assembly. We elucidate the mechanism of aAGd-NW assembly and characterize their distinct features, which include a negative surface charge, ultrafine topography, and right-handed chirality. Additionally, aAGd-NWs not only enhance X-ray deposition but also inhibit DNA repair, thereby enhancing radiation-induced in situ vaccination. Consequently, the in situ vaccination induced by aAGd-NWs sensitizes radiation enhances CD8+ T-cell-dependent antitumor immunity and synergistically potentiates the efficacy immune checkpoint blockade therapies against both primary and metastatic tumors. The well-established aAGd-NWs exhibit exceptional therapeutic capacity and biocompatibility, offering a promising avenue for the development of radioimmunotherapy approaches.

Suggested Citation

  • Zhusheng Huang & Rong Gu & Shiqian Huang & Qian Chen & Jing Yan & Xiaoya Cui & Haojie Jiang & Dan Yao & Chuang Shen & Jiayue Su & Tao Liu & Jinhui Wu & Zhimin Luo & Yiqiao Hu & Ahu Yuan, 2024. "Chiral coordination polymer nanowires boost radiation-induced in situ tumor vaccination," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-48423-w
    DOI: 10.1038/s41467-024-48423-w
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    References listed on IDEAS

    as
    1. Michael Eisenstein, 2011. "Vaccines: Know your enemy," Nature, Nature, vol. 471(7339), pages 8-9, March.
    2. Samantha L. Sanford & Griffin A. Welfer & Bret D. Freudenthal & Patricia L. Opresko, 2020. "Mechanisms of telomerase inhibition by oxidized and therapeutic dNTPs," Nature Communications, Nature, vol. 11(1), pages 1-12, December.
    3. Zhusheng Huang & Yuxiang Wang & Dan Yao & Jinhui Wu & Yiqiao Hu & Ahu Yuan, 2021. "Nanoscale coordination polymers induce immunogenic cell death by amplifying radiation therapy mediated oxidative stress," Nature Communications, Nature, vol. 12(1), pages 1-18, December.
    4. Bert van de Kooij & Alex Kruswick & Haico van Attikum & Michael B. Yaffe, 2022. "Multi-pathway DNA-repair reporters reveal competition between end-joining, single-strand annealing and homologous recombination at Cas9-induced DNA double-strand breaks," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    5. Weihua Zhou & Yangyang Yao & Andrew J. Scott & Kari Wilder-Romans & Joseph J. Dresser & Christian K. Werner & Hanshi Sun & Drew Pratt & Peter Sajjakulnukit & Shuang G. Zhao & Mary Davis & Barbara S. N, 2020. "Purine metabolism regulates DNA repair and therapy resistance in glioblastoma," Nature Communications, Nature, vol. 11(1), pages 1-14, December.
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    Cited by:

    1. Zhusheng Huang & Shiqian Huang & Simin Song & Yankui Ding & Hao Zhou & Shaoyin Zhang & Lixing Weng & Ying Zhang & Yiqiao Hu & Ahu Yuan & Yunlu Dai & Zhimin Luo & Lianhui Wang, 2024. "Two-dimensional coordination risedronate-manganese nanobelts as adjuvant for cancer radiotherapy and immunotherapy," Nature Communications, Nature, vol. 15(1), pages 1-20, December.

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