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Nanoparticle elasticity affects systemic circulation lifetime by modulating adsorption of apolipoprotein A-I in corona formation

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  • Mingyang Li

    (University of Science and Technology of China
    University of Science and Technology of China
    University of Science and Technology of China)

  • Xinyang Jin

    (University of Science and Technology of China
    University of Science and Technology of China
    University of Science and Technology of China)

  • Tao Liu

    (University of Science and Technology of China
    University of Science and Technology of China
    University of Science and Technology of China)

  • Feng Fan

    (University of Science and Technology of China
    University of Science and Technology of China
    University of Science and Technology of China)

  • Feng Gao

    (University of Science and Technology of China
    University of Science and Technology of China
    University of Science and Technology of China)

  • Shuang Chai

    (University of Science and Technology of China
    University of Science and Technology of China
    University of Science and Technology of China)

  • Lihua Yang

    (University of Science and Technology of China
    University of Science and Technology of China
    University of Science and Technology of China)

Abstract

Nanoparticle elasticity is crucial in nanoparticles’ physiological fate, but how this occurs is largely unknown. Using core-shell nanoparticles with a same PEGylated lipid bilayer shell yet cores differing in elasticity (45 kPa – 760 MPa) as models, we isolate the effects of nanoparticle elasticity from those of other physiochemical parameters and, using mouse models, observe a non-monotonic relationship of systemic circulation lifetime versus nanoparticle elasticity. Incubating our nanoparticles in mouse plasma provides protein coronas varying non-monotonically in composition depending on nanoparticle elasticity. Particularly, apolipoprotein A-I (ApoA1) is the only protein whose relative abundance in corona strongly correlates with our nanoparticles’ blood clearance lifetime. Notably, similar results are observed when above nanoparticles’ PEGylated lipid bilayer shell is changed to be non-PEGylated. This work unveils the mechanisms by which nanoparticle elasticity affects nanoparticles’ physiological fate and suggests nanoparticle elasticity as a readily tunable parameter in future rational exploiting of protein corona.

Suggested Citation

  • Mingyang Li & Xinyang Jin & Tao Liu & Feng Fan & Feng Gao & Shuang Chai & Lihua Yang, 2022. "Nanoparticle elasticity affects systemic circulation lifetime by modulating adsorption of apolipoprotein A-I in corona formation," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
  • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-31882-4
    DOI: 10.1038/s41467-022-31882-4
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    References listed on IDEAS

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    1. Nicolas Bertrand & Philippe Grenier & Morteza Mahmoudi & Eliana M. Lima & Eric A. Appel & Flavio Dormont & Jong-Min Lim & Rohit Karnik & Robert Langer & Omid C. Farokhzad, 2017. "Mechanistic understanding of in vivo protein corona formation on polymeric nanoparticles and impact on pharmacokinetics," Nature Communications, Nature, vol. 8(1), pages 1-8, December.
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    1. Junguang Wu & Xuan Bai & Liang Yan & Didar Baimanov & Yalin Cong & Peiyu Quan & Rui Cai & Yong Guan & Wei Bu & Binhua Lin & Jing Wang & Shengtao Yu & Shijiao Li & Yu Chong & Yang Li & Guoqing Hu & Yul, 2024. "Selective regulation of macrophage lipid metabolism via nanomaterials’ surface chemistry," Nature Communications, Nature, vol. 15(1), pages 1-18, December.

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