IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v14y2023i1d10.1038_s41467-023-37150-3.html
   My bibliography  Save this article

Mechano-boosting nanomedicine antitumour efficacy by blocking the reticuloendothelial system with stiff nanogels

Author

Listed:
  • Zheng Li

    (Huazhong University of Science and Technology)

  • Yabo Zhu

    (Huazhong University of Science and Technology)

  • Haowen Zeng

    (Huazhong University of Science and Technology)

  • Chong Wang

    (Huazhong University of Science and Technology)

  • Chen Xu

    (Huazhong University of Science and Technology)

  • Qiang Wang

    (Huazhong University of Science and Technology)

  • Huimin Wang

    (Huazhong University of Science and Technology)

  • Shiyou Li

    (Huazhong University of Science and Technology)

  • Jitang Chen

    (Huazhong University of Science and Technology)

  • Chen Xiao

    (Huazhong University of Science and Technology)

  • Xiangliang Yang

    (Huazhong University of Science and Technology
    Huazhong University of Science and Technology
    Huazhong University of Science and Technology
    GBA Research Innovation Institute for Nanotechnology)

  • Zifu Li

    (Huazhong University of Science and Technology
    Huazhong University of Science and Technology
    Huazhong University of Science and Technology
    Huazhong University of Science and Technology)

Abstract

Nanomedicine has been developed for cancer therapy over several decades, while rapid clearance from blood circulation by reticuloendothelial system (RES) severely limits nanomedicine antitumour efficacy. We design a series of nanogels with distinctive stiffness and investigate how nanogel mechanical properties could be leveraged to overcome RES. Stiff nanogels are injected preferentially to abrogate uptake capacity of macrophages and temporarily block RES, relying on inhibition of clathrin and prolonged liver retention. Afterwards, soft nanogels deliver doxorubicin (DOX) with excellent efficiency, reflected in high tumour accumulation, deep tumour penetration and outstanding antitumour efficacy. In this work, we combine the advantage of stiff nanogels in RES-blockade with the superiority of soft nanogels in drug delivery leads to the optimum tumour inhibition effect, which is defined as mechano-boosting antitumour strategy. Clinical implications of stiffness-dependent RES-blockade are also confirmed by promoting antitumour efficacy of commercialized nanomedicines, such as Doxil and Abraxane.

Suggested Citation

  • Zheng Li & Yabo Zhu & Haowen Zeng & Chong Wang & Chen Xu & Qiang Wang & Huimin Wang & Shiyou Li & Jitang Chen & Chen Xiao & Xiangliang Yang & Zifu Li, 2023. "Mechano-boosting nanomedicine antitumour efficacy by blocking the reticuloendothelial system with stiff nanogels," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
  • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-37150-3
    DOI: 10.1038/s41467-023-37150-3
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-023-37150-3
    File Function: Abstract
    Download Restriction: no

    File URL: https://libkey.io/10.1038/s41467-023-37150-3?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Peng Guo & Daxing Liu & Kriti Subramanyam & Biran Wang & Jiang Yang & Jing Huang & Debra T. Auguste & Marsha A. Moses, 2018. "Nanoparticle elasticity directs tumor uptake," Nature Communications, Nature, vol. 9(1), pages 1-9, December.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Ivan V. Zelepukin & Konstantin G. Shevchenko & Sergey M. Deyev, 2024. "Rediscovery of mononuclear phagocyte system blockade for nanoparticle drug delivery," Nature Communications, Nature, vol. 15(1), pages 1-14, December.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Jia He & Chaoyu Wang & Xiao Fang & Junyao Li & Xueying Shen & Junxia Zhang & Cheng Peng & Hongjian Li & Sai Li & Jeffrey M. Karp & Rui Kuai, 2024. "Tuning the fluidity and protein corona of ultrasound-responsive liposomal nanovaccines to program T cell immunity in mice," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    2. Yue Jiang & Min Zhao & Jia Miao & Wan Chen & Yuan Zhang & Minqian Miao & Li Yang & Qing Li & Qingqing Miao, 2024. "Acidity-activatable upconversion afterglow luminescence cocktail nanoparticles for ultrasensitive in vivo imaging," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    3. Sam J. Parkinson & Sireethorn Tungsirisurp & Chitra Joshi & Bethany L. Richmond & Miriam L. Gifford & Amrita Sikder & Iseult Lynch & Rachel K. O’Reilly & Richard M. Napier, 2022. "Polymer nanoparticles pass the plant interface," Nature Communications, Nature, vol. 13(1), pages 1-9, December.
    4. Mingyang Li & Xinyang Jin & Tao Liu & Feng Fan & Feng Gao & Shuang Chai & Lihua Yang, 2022. "Nanoparticle elasticity affects systemic circulation lifetime by modulating adsorption of apolipoprotein A-I in corona formation," Nature Communications, Nature, vol. 13(1), pages 1-16, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-37150-3. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.