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Brain-targeted drug delivery by manipulating protein corona functions

Author

Listed:
  • Zui Zhang

    (Fudan University
    School of Pharmacy & Key Laboratory of Smart Drug Delivery (Fudan University), Ministry of Education)

  • Juan Guan

    (Fudan University)

  • Zhuxuan Jiang

    (Fudan University)

  • Yang Yang

    (Fudan University)

  • Jican Liu

    (Fudan University)

  • Wei Hua

    (Huashan Hospital Fudan University)

  • Ying Mao

    (Huashan Hospital Fudan University)

  • Cheng Li

    (School of Pharmacy & Key Laboratory of Smart Drug Delivery (Fudan University), Ministry of Education)

  • Weiyue Lu

    (School of Pharmacy & Key Laboratory of Smart Drug Delivery (Fudan University), Ministry of Education)

  • Jun Qian

    (School of Pharmacy & Key Laboratory of Smart Drug Delivery (Fudan University), Ministry of Education)

  • Changyou Zhan

    (Fudan University
    School of Pharmacy & Key Laboratory of Smart Drug Delivery (Fudan University), Ministry of Education)

Abstract

Protein corona presents a major obstacle to bench-to-bedside translation of targeted drug delivery systems, severely affecting targeting yields and directing unfavorable biodistribution. Corona-mediated targeting provides a new impetus for specific drug delivery by precisely manipulating interaction modes of functional plasma proteins on nano-surface. Here bio-inspired liposomes (SP-sLip) were developed by modifying liposomal surface with a short nontoxic peptide derived from Aβ1-42 that specifically interacts with the lipid-binding domain of exchangeable apolipoproteins. SP-sLip absorb plasma apolipoproteins A1, E and J, consequently exposing receptor-binding domain of apolipoproteins to achieve brain-targeted delivery. Doxorubicin loaded SP-sLip (SP-sLip/DOX) show significant enhancement of brain distribution and anti-brain cancer effect in comparison to doxorubicin loaded plain liposomes. SP-sLip preserve functions of the absorbed human plasma ApoE, and the corona-mediated targeting strategy works in SP modified PLGA nanoparticles. The present study may pave a new avenue to facilitate clinical translation of targeted drug delivery systems.

Suggested Citation

  • Zui Zhang & Juan Guan & Zhuxuan Jiang & Yang Yang & Jican Liu & Wei Hua & Ying Mao & Cheng Li & Weiyue Lu & Jun Qian & Changyou Zhan, 2019. "Brain-targeted drug delivery by manipulating protein corona functions," Nature Communications, Nature, vol. 10(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-11593-z
    DOI: 10.1038/s41467-019-11593-z
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    Cited by:

    1. Lin Li & Mengxing Zhang & Jing Li & Tiantian Liu & Qixue Bao & Xi Li & Jiaying Long & Leyao Fu & Zhirong Zhang & Shiqi Huang & Zhenmi Liu & Ling Zhang, 2023. "Cholesterol removal improves performance of a model biomimetic system to co-deliver a photothermal agent and a STING agonist for cancer immunotherapy," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    2. Wei Jiang & Qing Li & Ruofei Zhang & Jianru Li & Qianyu Lin & Jingyun Li & Xinyao Zhou & Xiyun Yan & Kelong Fan, 2023. "Chiral metal-organic frameworks incorporating nanozymes as neuroinflammation inhibitors for managing Parkinson’s disease," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    3. Mingyang Li & Xinyang Jin & Tao Liu & Feng Fan & Feng Gao & Shuang Chai & Lihua Yang, 2022. "Nanoparticle elasticity affects systemic circulation lifetime by modulating adsorption of apolipoprotein A-I in corona formation," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    4. Ali Akbar Ashkarran & Hassan Gharibi & Elizabeth Voke & Markita P. Landry & Amir Ata Saei & Morteza Mahmoudi, 2022. "Measurements of heterogeneity in proteomics analysis of the nanoparticle protein corona across core facilities," Nature Communications, Nature, vol. 13(1), pages 1-11, December.

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