IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v9y2018i1d10.1038_s41467-017-02588-9.html
   My bibliography  Save this article

Nanoparticle elasticity directs tumor uptake

Author

Listed:
  • Peng Guo

    (Boston Children’s Hospital
    Harvard Medical School and Boston Children’s Hospital
    The City College of New York)

  • Daxing Liu

    (The City College of New York
    Northeastern University)

  • Kriti Subramanyam

    (Boston Children’s Hospital
    Harvard University
    Massachusetts Institute of Technology)

  • Biran Wang

    (The City College of New York
    Texas A&M University)

  • Jiang Yang

    (Boston Children’s Hospital
    Harvard Medical School and Boston Children’s Hospital)

  • Jing Huang

    (Boston Children’s Hospital
    Harvard Medical School and Boston Children’s Hospital)

  • Debra T. Auguste

    (The City College of New York
    Northeastern University)

  • Marsha A. Moses

    (Boston Children’s Hospital
    Harvard Medical School and Boston Children’s Hospital)

Abstract

To date, the role of elasticity in drug delivery remains elusive due to the inability to measure microscale mechanics and alter rheology without affecting chemistry. Herein, we describe the in vitro cellular uptake and in vivo tumor uptake of nanolipogels (NLGs). NLGs are composed of identical lipid bilayers encapsulating an alginate core, with tunable elasticity. The elasticity of NLGs was evaluated by atomic force microscopy, which demonstrated that they exhibit Young’s moduli ranging from 45 ± 9 to 19,000 ± 5 kPa. Neoplastic and non-neoplastic cells exhibited significantly greater uptake of soft NLGs (Young’s modulus 13.8 MPa). In an orthotopic breast tumor model, soft NLGs accumulated significantly more in tumors, whereas elastic NLGs preferentially accumulated in the liver. Our findings demonstrate that particle elasticity directs tumor accumulation, suggesting that it may be a design parameter to enhance tumor delivery efficiency.

Suggested Citation

  • Peng Guo & Daxing Liu & Kriti Subramanyam & Biran Wang & Jiang Yang & Jing Huang & Debra T. Auguste & Marsha A. Moses, 2018. "Nanoparticle elasticity directs tumor uptake," Nature Communications, Nature, vol. 9(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-017-02588-9
    DOI: 10.1038/s41467-017-02588-9
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-017-02588-9
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-017-02588-9?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Sam J. Parkinson & Sireethorn Tungsirisurp & Chitra Joshi & Bethany L. Richmond & Miriam L. Gifford & Amrita Sikder & Iseult Lynch & Rachel K. O’Reilly & Richard M. Napier, 2022. "Polymer nanoparticles pass the plant interface," Nature Communications, Nature, vol. 13(1), pages 1-9, December.
    2. Mingyang Li & Xinyang Jin & Tao Liu & Feng Fan & Feng Gao & Shuang Chai & Lihua Yang, 2022. "Nanoparticle elasticity affects systemic circulation lifetime by modulating adsorption of apolipoprotein A-I in corona formation," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    3. Yue Jiang & Min Zhao & Jia Miao & Wan Chen & Yuan Zhang & Minqian Miao & Li Yang & Qing Li & Qingqing Miao, 2024. "Acidity-activatable upconversion afterglow luminescence cocktail nanoparticles for ultrasensitive in vivo imaging," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    4. Zheng Li & Yabo Zhu & Haowen Zeng & Chong Wang & Chen Xu & Qiang Wang & Huimin Wang & Shiyou Li & Jitang Chen & Chen Xiao & Xiangliang Yang & Zifu Li, 2023. "Mechano-boosting nanomedicine antitumour efficacy by blocking the reticuloendothelial system with stiff nanogels," Nature Communications, Nature, vol. 14(1), pages 1-18, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-017-02588-9. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.