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Nanoparticle elasticity directs tumor uptake

Author

Listed:
  • Peng Guo

    (Boston Children’s Hospital
    Harvard Medical School and Boston Children’s Hospital
    The City College of New York)

  • Daxing Liu

    (The City College of New York
    Northeastern University)

  • Kriti Subramanyam

    (Boston Children’s Hospital
    Harvard University
    Massachusetts Institute of Technology)

  • Biran Wang

    (The City College of New York
    Texas A&M University)

  • Jiang Yang

    (Boston Children’s Hospital
    Harvard Medical School and Boston Children’s Hospital)

  • Jing Huang

    (Boston Children’s Hospital
    Harvard Medical School and Boston Children’s Hospital)

  • Debra T. Auguste

    (The City College of New York
    Northeastern University)

  • Marsha A. Moses

    (Boston Children’s Hospital
    Harvard Medical School and Boston Children’s Hospital)

Abstract

To date, the role of elasticity in drug delivery remains elusive due to the inability to measure microscale mechanics and alter rheology without affecting chemistry. Herein, we describe the in vitro cellular uptake and in vivo tumor uptake of nanolipogels (NLGs). NLGs are composed of identical lipid bilayers encapsulating an alginate core, with tunable elasticity. The elasticity of NLGs was evaluated by atomic force microscopy, which demonstrated that they exhibit Young’s moduli ranging from 45 ± 9 to 19,000 ± 5 kPa. Neoplastic and non-neoplastic cells exhibited significantly greater uptake of soft NLGs (Young’s modulus 13.8 MPa). In an orthotopic breast tumor model, soft NLGs accumulated significantly more in tumors, whereas elastic NLGs preferentially accumulated in the liver. Our findings demonstrate that particle elasticity directs tumor accumulation, suggesting that it may be a design parameter to enhance tumor delivery efficiency.

Suggested Citation

  • Peng Guo & Daxing Liu & Kriti Subramanyam & Biran Wang & Jiang Yang & Jing Huang & Debra T. Auguste & Marsha A. Moses, 2018. "Nanoparticle elasticity directs tumor uptake," Nature Communications, Nature, vol. 9(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-017-02588-9
    DOI: 10.1038/s41467-017-02588-9
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    Cited by:

    1. Jia He & Chaoyu Wang & Xiao Fang & Junyao Li & Xueying Shen & Junxia Zhang & Cheng Peng & Hongjian Li & Sai Li & Jeffrey M. Karp & Rui Kuai, 2024. "Tuning the fluidity and protein corona of ultrasound-responsive liposomal nanovaccines to program T cell immunity in mice," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    2. Sam J. Parkinson & Sireethorn Tungsirisurp & Chitra Joshi & Bethany L. Richmond & Miriam L. Gifford & Amrita Sikder & Iseult Lynch & Rachel K. O’Reilly & Richard M. Napier, 2022. "Polymer nanoparticles pass the plant interface," Nature Communications, Nature, vol. 13(1), pages 1-9, December.
    3. Mingyang Li & Xinyang Jin & Tao Liu & Feng Fan & Feng Gao & Shuang Chai & Lihua Yang, 2022. "Nanoparticle elasticity affects systemic circulation lifetime by modulating adsorption of apolipoprotein A-I in corona formation," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    4. Yue Jiang & Min Zhao & Jia Miao & Wan Chen & Yuan Zhang & Minqian Miao & Li Yang & Qing Li & Qingqing Miao, 2024. "Acidity-activatable upconversion afterglow luminescence cocktail nanoparticles for ultrasensitive in vivo imaging," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    5. Zheng Li & Yabo Zhu & Haowen Zeng & Chong Wang & Chen Xu & Qiang Wang & Huimin Wang & Shiyou Li & Jitang Chen & Chen Xiao & Xiangliang Yang & Zifu Li, 2023. "Mechano-boosting nanomedicine antitumour efficacy by blocking the reticuloendothelial system with stiff nanogels," Nature Communications, Nature, vol. 14(1), pages 1-18, December.

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