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Selective regulation of macrophage lipid metabolism via nanomaterials’ surface chemistry

Author

Listed:
  • Junguang Wu

    (National Center for Nanoscience and Technology of China
    University of Chinese Academy of Sciences
    Chinese Academy of Sciences)

  • Xuan Bai

    (Zhejiang University
    Inc)

  • Liang Yan

    (National Center for Nanoscience and Technology of China)

  • Didar Baimanov

    (National Center for Nanoscience and Technology of China
    Chinese Academy of Sciences)

  • Yalin Cong

    (National Center for Nanoscience and Technology of China
    Chinese Academy of Sciences)

  • Peiyu Quan

    (National Center for Nanoscience and Technology of China
    The University of Chicago)

  • Rui Cai

    (National Center for Nanoscience and Technology of China
    Chinese Academy of Sciences)

  • Yong Guan

    (University of Science and Technology of China)

  • Wei Bu

    (The University of Chicago)

  • Binhua Lin

    (The University of Chicago)

  • Jing Wang

    (Peking University)

  • Shengtao Yu

    (National Center for Nanoscience and Technology of China)

  • Shijiao Li

    (National Center for Nanoscience and Technology of China)

  • Yu Chong

    (Soochow University)

  • Yang Li

    (Chinese Academy of Sciences)

  • Guoqing Hu

    (Zhejiang University)

  • Yuliang Zhao

    (National Center for Nanoscience and Technology of China
    Guangzhou
    Chinese Academy of Medical Sciences)

  • Chunying Chen

    (National Center for Nanoscience and Technology of China
    Guangzhou
    Chinese Academy of Medical Sciences)

  • Liming Wang

    (National Center for Nanoscience and Technology of China
    Chinese Academy of Sciences)

Abstract

Understanding the interface between nanomaterials and lipoproteins is crucial for gaining insights into their impact on lipoprotein structure and lipid metabolism. Here, we use graphene oxide (GOs) nanosheets as a controlled carbon nanomaterial model to study how surface properties influence lipoprotein corona formation and show that GOs have strong binding affinity with low-density lipoprotein (LDL). We use advanced techniques including X-ray reflectivity, circular dichroism, and molecular simulations to explore the interfacial interactions between GOs and LDL. Specifically, hydrophobic GOs preferentially associate with LDL’s lipid components, whereas hydrophilic GOs tend to bind with apolipoproteins. Furthermore, these GOs distinctly modulate a variety of lipid metabolism pathways, including LDL recognition, uptake, hydrolysis, efflux, and lipid droplet formation. This study underscores the importance of structure analysis at the nano-biomolecule interface, emphasizing how nanomaterials’ surface properties critically influence cellular lipid metabolism. These insights will inspire the design and application of future biocompatible nanomaterials and nanomedicines.

Suggested Citation

  • Junguang Wu & Xuan Bai & Liang Yan & Didar Baimanov & Yalin Cong & Peiyu Quan & Rui Cai & Yong Guan & Wei Bu & Binhua Lin & Jing Wang & Shengtao Yu & Shijiao Li & Yu Chong & Yang Li & Guoqing Hu & Yul, 2024. "Selective regulation of macrophage lipid metabolism via nanomaterials’ surface chemistry," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-52609-7
    DOI: 10.1038/s41467-024-52609-7
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    References listed on IDEAS

    as
    1. Kai Liu & Ralf Nilsson & Elisa Lázaro-Ibáñez & Hanna Duàn & Tasso Miliotis & Marie Strimfors & Michael Lerche & Ana Rita Salgado Ribeiro & Johan Ulander & Daniel Lindén & Anna Salvati & Alan Sabirsh, 2023. "Multiomics analysis of naturally efficacious lipid nanoparticle coronas reveals high-density lipoprotein is necessary for their function," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    2. Xiang Lu & Peipei Xu & Hong-Ming Ding & You-Sheng Yu & Da Huo & Yu-Qiang Ma, 2019. "Tailoring the component of protein corona via simple chemistry," Nature Communications, Nature, vol. 10(1), pages 1-14, December.
    3. Mingyang Li & Xinyang Jin & Tao Liu & Feng Fan & Feng Gao & Shuang Chai & Lihua Yang, 2022. "Nanoparticle elasticity affects systemic circulation lifetime by modulating adsorption of apolipoprotein A-I in corona formation," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
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