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Wearable smart sensor systems integrated on soft contact lenses for wireless ocular diagnostics

Author

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  • Joohee Kim

    (School of Materials Science and Engineering, School of Energy and Chemical Engineering, Wearable Electronics Research Group, Center for Smart Sensor Systems, Ulsan National Institute of Science and Technology (UNIST))

  • Minji Kim

    (School of Materials Science and Engineering, School of Energy and Chemical Engineering, Wearable Electronics Research Group, Center for Smart Sensor Systems, Ulsan National Institute of Science and Technology (UNIST))

  • Mi-Sun Lee

    (School of Materials Science and Engineering, School of Energy and Chemical Engineering, Wearable Electronics Research Group, Center for Smart Sensor Systems, Ulsan National Institute of Science and Technology (UNIST))

  • Kukjoo Kim

    (School of Materials Science and Engineering, School of Energy and Chemical Engineering, Wearable Electronics Research Group, Center for Smart Sensor Systems, Ulsan National Institute of Science and Technology (UNIST))

  • Sangyoon Ji

    (School of Materials Science and Engineering, School of Energy and Chemical Engineering, Wearable Electronics Research Group, Center for Smart Sensor Systems, Ulsan National Institute of Science and Technology (UNIST))

  • Yun-Tae Kim

    (School of Life Sciences, School of Energy and Chemical Engineering, Ulsan National Institute of Science and Technology (UNIST))

  • Jihun Park

    (School of Materials Science and Engineering, School of Energy and Chemical Engineering, Wearable Electronics Research Group, Center for Smart Sensor Systems, Ulsan National Institute of Science and Technology (UNIST))

  • Kyungmin Na

    (School of Electrical and Computer Engineering, Ulsan National Institute of Science and Technology (UNIST))

  • Kwi-Hyun Bae

    (Kyungpook National University School of Medicine)

  • Hong Kyun Kim

    (Kyungpook National University School of Medicine)

  • Franklin Bien

    (School of Electrical and Computer Engineering, Ulsan National Institute of Science and Technology (UNIST))

  • Chang Young Lee

    (School of Life Sciences, School of Energy and Chemical Engineering, Ulsan National Institute of Science and Technology (UNIST))

  • Jang-Ung Park

    (School of Materials Science and Engineering, School of Energy and Chemical Engineering, Wearable Electronics Research Group, Center for Smart Sensor Systems, Ulsan National Institute of Science and Technology (UNIST))

Abstract

Wearable contact lenses which can monitor physiological parameters have attracted substantial interests due to the capability of direct detection of biomarkers contained in body fluids. However, previously reported contact lens sensors can only monitor a single analyte at a time. Furthermore, such ocular contact lenses generally obstruct the field of vision of the subject. Here, we developed a multifunctional contact lens sensor that alleviates some of these limitations since it was developed on an actual ocular contact lens. It was also designed to monitor glucose within tears, as well as intraocular pressure using the resistance and capacitance of the electronic device. Furthermore, in-vivo and in-vitro tests using a live rabbit and bovine eyeball demonstrated its reliable operation. Our developed contact lens sensor can measure the glucose level in tear fluid and intraocular pressure simultaneously but yet independently based on different electrical responses.

Suggested Citation

  • Joohee Kim & Minji Kim & Mi-Sun Lee & Kukjoo Kim & Sangyoon Ji & Yun-Tae Kim & Jihun Park & Kyungmin Na & Kwi-Hyun Bae & Hong Kyun Kim & Franklin Bien & Chang Young Lee & Jang-Ung Park, 2017. "Wearable smart sensor systems integrated on soft contact lenses for wireless ocular diagnostics," Nature Communications, Nature, vol. 8(1), pages 1-8, April.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms14997
    DOI: 10.1038/ncomms14997
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    Cited by:

    1. Hengtian Zhu & Huan Yang & Siqi Xu & Yuanyuan Ma & Shugeng Zhu & Zhengyi Mao & Weiwei Chen & Zizhong Hu & Rongrong Pan & Yurui Xu & Yifeng Xiong & Ye Chen & Yanqing Lu & Xinghai Ning & Dechen Jiang & , 2024. "Frequency-encoded eye tracking smart contact lens for human–machine interaction," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    2. Tae Yeon Kim & Jee Won Mok & Sang Hoon Hong & Sang Hoon Jeong & Hyunsik Choi & Sangbaie Shin & Choun-Ki Joo & Sei Kwang Hahn, 2022. "Wireless theranostic smart contact lens for monitoring and control of intraocular pressure in glaucoma," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    3. Vidal, João V. & Rolo, Pedro & Carneiro, Pedro M.R. & Peres, Inês & Kholkin, Andrei L. & Soares dos Santos, Marco P., 2022. "Automated electromagnetic generator with self-adaptive structure by coil switching," Applied Energy, Elsevier, vol. 325(C).
    4. Jinyuan Zhang & Kyunghun Kim & Ho Joong Kim & Dawn Meyer & Woohyun Park & Seul Ah Lee & Yumin Dai & Bongjoong Kim & Haesoo Moon & Jay V. Shah & Keely E. Harris & Brett Collar & Kangying Liu & Pedro Ir, 2022. "Smart soft contact lenses for continuous 24-hour monitoring of intraocular pressure in glaucoma care," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    5. Cheng Yang & Qianni Wu & Junqing Liu & Jingshan Mo & Xiangling Li & Chengduan Yang & Ziqi Liu & Jingbo Yang & Lelun Jiang & Weirong Chen & Hui-jiuan Chen & Ji Wang & Xi Xie, 2022. "Intelligent wireless theranostic contact lens for electrical sensing and regulation of intraocular pressure," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    6. Weijia Liu & Zhijian Du & Zhongyi Duan & La Li & Guozhen Shen, 2024. "Neuroprosthetic contact lens enabled sensorimotor system for point-of-care monitoring and feedback of intraocular pressure," Nature Communications, Nature, vol. 15(1), pages 1-10, December.
    7. Bekir Aksoy & Yufei Hao & Giulio Grasso & Krishna Manaswi Digumarti & Vito Cacucciolo & Herbert Shea, 2022. "Shielded soft force sensors," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    8. Xia Zhu & Ke Wu & Xiaohang Xie & Stephan W. Anderson & Xin Zhang, 2024. "A robust near-field body area network based on coaxially-shielded textile metamaterial," Nature Communications, Nature, vol. 15(1), pages 1-12, December.

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