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Construction of emissive ruthenium(II) metallacycle over 1000 nm wavelength for in vivo biomedical applications

Author

Listed:
  • Yuling Xu

    (Central China Normal University)

  • Chonglu Li

    (Central China Normal University)

  • Shuai Lu

    (Shenzhen University General Hospital, Shenzhen University Clinical Medical Academy, Shenzhen
    Shenzhen University)

  • Zhizheng Wang

    (Central China Normal University
    South China University of Technology)

  • Shuang Liu

    (Wuhan University of Technology)

  • Xiujun Yu

    (Shenzhen University General Hospital, Shenzhen University Clinical Medical Academy, Shenzhen
    Shenzhen University)

  • Xiaopeng Li

    (Shenzhen University General Hospital, Shenzhen University Clinical Medical Academy, Shenzhen
    Shenzhen University)

  • Yao Sun

    (Central China Normal University)

Abstract

Although Ru(II)-based agents are expected to be promising candidates for substituting Pt-drug, their in vivo biomedical applications are still limited by the short excitation/emission wavelengths and unsatisfactory therapeutic efficiency. Herein, we rationally design a Ru(II) metallacycle with excitation at 808 nm and emission over 1000 nm, namely Ru1085, which holds deep optical penetration (up to 6 mm) and enhanced chemo-phototherapy activity. In vitro studies indicate that Ru1085 exhibits prominent cell uptake and desirable anticancer capability against various cancer cell lines, especially for cisplatin-resistant A549 cells. Further studies reveal Ru1085 induces mitochondria-mediated apoptosis along with S and G2/M phase cell cycle arrest. Finally, Ru1085 shows precise NIR-II fluorescence imaging guided and long-term monitored chemo-phototherapy against A549 tumor with minimal side effects. We envision that the design of long-wavelength emissive metallacycle will offer emerging opportunities of metal-based agents for in vivo biomedical applications.

Suggested Citation

  • Yuling Xu & Chonglu Li & Shuai Lu & Zhizheng Wang & Shuang Liu & Xiujun Yu & Xiaopeng Li & Yao Sun, 2022. "Construction of emissive ruthenium(II) metallacycle over 1000 nm wavelength for in vivo biomedical applications," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-29572-2
    DOI: 10.1038/s41467-022-29572-2
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    References listed on IDEAS

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    1. Johannes Karges & Shi Kuang & Federica Maschietto & Olivier Blacque & Ilaria Ciofini & Hui Chao & Gilles Gasser, 2020. "Rationally designed ruthenium complexes for 1- and 2-photon photodynamic therapy," Nature Communications, Nature, vol. 11(1), pages 1-13, December.
    2. Lingfei Lu & Benhao Li & Suwan Ding & Yong Fan & Shangfeng Wang & Caixia Sun & Mengyao Zhao & Chun-Xia Zhao & Fan Zhang, 2020. "NIR-II bioluminescence for in vivo high contrast imaging and in situ ATP-mediated metastases tracing," Nature Communications, Nature, vol. 11(1), pages 1-11, December.
    3. Jun-Long Zhu & Lin Xu & Yuan-Yuan Ren & Ying Zhang & Xi Liu & Guang-Qiang Yin & Bin Sun & Xiaodan Cao & Zhuang Chen & Xiao-Li Zhao & Hongwei Tan & Jinquan Chen & Xiaopeng Li & Hai-Bo Yang, 2019. "Switchable organoplatinum metallacycles with high quantum yields and tunable fluorescence wavelengths," Nature Communications, Nature, vol. 10(1), pages 1-12, December.
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