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A supramolecular photosensitizer derived from an Arene-Ru(II) complex self-assembly for NIR activated photodynamic and photothermal therapy

Author

Listed:
  • Gang Xu

    (Southeast University)

  • Chengwei Li

    (Southeast University)

  • Chen Chi

    (Nanjing University)

  • Luyan Wu

    (Nanjing University)

  • Yanyan Sun

    (Suzhou University of Science and Technology)

  • Jian Zhao

    (Southeast University)

  • Xing-Hua Xia

    (Nanjing University)

  • Shaohua Gou

    (Southeast University)

Abstract

Effective photosensitizers are of particular importance for the widespread clinical utilization of phototherapy. However, conventional photosensitizers are usually plagued by short-wavelength absorption, inadequate photostability, low reactive oxygen species (ROS) quantum yields, and aggregation-caused ROS quenching. Here, we report a near-infrared (NIR)-supramolecular photosensitizer (RuDA) via self-assembly of an organometallic Ru(II)-arene complex in aqueous solution. RuDA can generate singlet oxygen (1O2) only in aggregate state, showing distinct aggregation-induced 1O2 generation behavior due to the greatly increased singlet-triplet intersystem crossing process. Upon 808 nm laser irradiation, RuDA with excellent photostability displays efficient 1O2 and heat generation in a 1O2 quantum yield of 16.4% (FDA-approved indocyanine green: ΦΔ = 0.2%) together with high photothermal conversion efficiency of 24.2% (commercial gold nanorods: 21.0%, gold nanoshells: 13.0%). In addition, RuDA-NPs with good biocompatibility can be preferably accumulated at tumor sites, inducing significant tumor regression with a 95.2% tumor volume reduction in vivo during photodynamic therapy. This aggregation enhanced photodynamic therapy provides a strategy for the design of photosensitizers with promising photophysical and photochemical characteristics.

Suggested Citation

  • Gang Xu & Chengwei Li & Chen Chi & Luyan Wu & Yanyan Sun & Jian Zhao & Xing-Hua Xia & Shaohua Gou, 2022. "A supramolecular photosensitizer derived from an Arene-Ru(II) complex self-assembly for NIR activated photodynamic and photothermal therapy," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-30721-w
    DOI: 10.1038/s41467-022-30721-w
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    References listed on IDEAS

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    1. Jianhui Yang & Yahui Zhang & Xinghui Wu & Wenbo Dai & Dan Chen & Jianbing Shi & Bin Tong & Qian Peng & Haiyan Xie & Zhengxu Cai & Yuping Dong & Xin Zhang, 2021. "Rational design of pyrrole derivatives with aggregation-induced phosphorescence characteristics for time-resolved and two-photon luminescence imaging," Nature Communications, Nature, vol. 12(1), pages 1-8, December.
    2. Johannes Karges & Shi Kuang & Federica Maschietto & Olivier Blacque & Ilaria Ciofini & Hui Chao & Gilles Gasser, 2020. "Rationally designed ruthenium complexes for 1- and 2-photon photodynamic therapy," Nature Communications, Nature, vol. 11(1), pages 1-13, December.
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    Cited by:

    1. Yufu Tang & Yuanyuan Li & Bowen Li & Wentao Song & Guobin Qi & Jianwu Tian & Wei Huang & Quli Fan & Bin Liu, 2024. "Oxygen-independent organic photosensitizer with ultralow-power NIR photoexcitation for tumor-specific photodynamic therapy," Nature Communications, Nature, vol. 15(1), pages 1-13, December.

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