IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v13y2022i1d10.1038_s41467-022-30721-w.html
   My bibliography  Save this article

A supramolecular photosensitizer derived from an Arene-Ru(II) complex self-assembly for NIR activated photodynamic and photothermal therapy

Author

Listed:
  • Gang Xu

    (Southeast University)

  • Chengwei Li

    (Southeast University)

  • Chen Chi

    (Nanjing University)

  • Luyan Wu

    (Nanjing University)

  • Yanyan Sun

    (Suzhou University of Science and Technology)

  • Jian Zhao

    (Southeast University)

  • Xing-Hua Xia

    (Nanjing University)

  • Shaohua Gou

    (Southeast University)

Abstract

Effective photosensitizers are of particular importance for the widespread clinical utilization of phototherapy. However, conventional photosensitizers are usually plagued by short-wavelength absorption, inadequate photostability, low reactive oxygen species (ROS) quantum yields, and aggregation-caused ROS quenching. Here, we report a near-infrared (NIR)-supramolecular photosensitizer (RuDA) via self-assembly of an organometallic Ru(II)-arene complex in aqueous solution. RuDA can generate singlet oxygen (1O2) only in aggregate state, showing distinct aggregation-induced 1O2 generation behavior due to the greatly increased singlet-triplet intersystem crossing process. Upon 808 nm laser irradiation, RuDA with excellent photostability displays efficient 1O2 and heat generation in a 1O2 quantum yield of 16.4% (FDA-approved indocyanine green: ΦΔ = 0.2%) together with high photothermal conversion efficiency of 24.2% (commercial gold nanorods: 21.0%, gold nanoshells: 13.0%). In addition, RuDA-NPs with good biocompatibility can be preferably accumulated at tumor sites, inducing significant tumor regression with a 95.2% tumor volume reduction in vivo during photodynamic therapy. This aggregation enhanced photodynamic therapy provides a strategy for the design of photosensitizers with promising photophysical and photochemical characteristics.

Suggested Citation

  • Gang Xu & Chengwei Li & Chen Chi & Luyan Wu & Yanyan Sun & Jian Zhao & Xing-Hua Xia & Shaohua Gou, 2022. "A supramolecular photosensitizer derived from an Arene-Ru(II) complex self-assembly for NIR activated photodynamic and photothermal therapy," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-30721-w
    DOI: 10.1038/s41467-022-30721-w
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-022-30721-w
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-022-30721-w?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Jianhui Yang & Yahui Zhang & Xinghui Wu & Wenbo Dai & Dan Chen & Jianbing Shi & Bin Tong & Qian Peng & Haiyan Xie & Zhengxu Cai & Yuping Dong & Xin Zhang, 2021. "Rational design of pyrrole derivatives with aggregation-induced phosphorescence characteristics for time-resolved and two-photon luminescence imaging," Nature Communications, Nature, vol. 12(1), pages 1-8, December.
    2. Johannes Karges & Shi Kuang & Federica Maschietto & Olivier Blacque & Ilaria Ciofini & Hui Chao & Gilles Gasser, 2020. "Rationally designed ruthenium complexes for 1- and 2-photon photodynamic therapy," Nature Communications, Nature, vol. 11(1), pages 1-13, December.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Yufu Tang & Yuanyuan Li & Bowen Li & Wentao Song & Guobin Qi & Jianwu Tian & Wei Huang & Quli Fan & Bin Liu, 2024. "Oxygen-independent organic photosensitizer with ultralow-power NIR photoexcitation for tumor-specific photodynamic therapy," Nature Communications, Nature, vol. 15(1), pages 1-13, December.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Tian Tian & Yuxuan Fang & Wenhui Wang & Meifang Yang & Ying Tan & Chuan Xu & Shuo Zhang & Yuxin Chen & Mingyi Xu & Bin Cai & Wu-Qiang Wu, 2023. "Durable organic nonlinear optical membranes for thermotolerant lightings and in vivo bioimaging," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    2. Yuling Xu & Chonglu Li & Shuai Lu & Zhizheng Wang & Shuang Liu & Xiujun Yu & Xiaopeng Li & Yao Sun, 2022. "Construction of emissive ruthenium(II) metallacycle over 1000 nm wavelength for in vivo biomedical applications," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    3. Xiao Wang & Wenjing Sun & Huifang Shi & Huili Ma & Guowei Niu & Yuxin Li & Jiahuan Zhi & Xiaokang Yao & Zhicheng Song & Lei Chen & Shi Li & Guohui Yang & Zixing Zhou & Yixiao He & Shuli Qu & Min Wu & , 2022. "Organic phosphorescent nanoscintillator for low-dose X-ray-induced photodynamic therapy," Nature Communications, Nature, vol. 13(1), pages 1-9, December.
    4. Nong Lu & Zhihong Deng & Jing Gao & Chao Liang & Haiping Xia & Pingyu Zhang, 2022. "An osmium-peroxo complex for photoactive therapy of hypoxic tumors," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    5. Guanqun Han & Guodong Li & Jie Huang & Chuang Han & Claudia Turro & Yujie Sun, 2022. "Two-photon-absorbing ruthenium complexes enable near infrared light-driven photocatalysis," Nature Communications, Nature, vol. 13(1), pages 1-10, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-30721-w. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.